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Raspberry-like nanogel-based material prepared by emulsion

Research Project

Project/Area Number 24860036
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biofunction/Bioprocess
Research InstitutionKyoto University

Principal Investigator

TAHARA Yoshiro  京都大学, 工学(系)研究科(研究院), 研究員 (30638383)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsナノゲル / 多糖 / エマルション / ドラッグデリバリー / タンパク質医薬
Research Abstract

Nanogel consisting of self-assembled polysaccharides is one of the most attractive carriers for drug delivery systems. In the present study, "raspberry-like nanogel-based material" was prepared by bottom-up approach using nanogels as building units. The effective control and design of the cross-linking and nano-domains in macro-scale hydrogels are important focuses of research. Raspberry-like nanogel-based material was prepared through cross-linking of nanogels in water-in-oil emulsion. The basic characters of raspberry-like nanogel-based materials were evaluated by confocal laser scanning microscopy and laser diffraction particle size analysis. The size of raspberry-like nanogel-based material was controlled in micrometer range. These findings suggested that raspberry-like nanogel-based material enables to be used as carrier for a novel drug delivery system.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (14 results)

All 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (6 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Pullulan2014

    • Author(s)
      Tahara Yoshiro
    • Journal Title

      Encyclopedia of polymeric nanomaterials

      Volume: 作成中

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Nanogel bottom-up gel biomaterials for protein delivery : photopolymerization of an acryloyl-modified polysaccharide nanogel macromonomer2013

    • Author(s)
      Yoshiro Tahara, Satoshi Kosuge, Shin-ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi
    • Journal Title

      Reactive and Functional Polymers

      Volume: 73(7)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nanogel bottom-up gel biomaterials for protein delivery: Photopolymerization of an acryloyl-modified polysaccharide nanogel macromonomer2013

    • Author(s)
      Y. Tahara, S. Kosuge, S. Sawada, Y. Sasaki, K. Akiyoshi
    • Journal Title

      Reactive and Functional Polymers

      Volume: 73 Issue: 7 Pages: 958-964

    • DOI

      10.1016/j.reactfunctpolym.2013.02.002

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pullulan

    • Author(s)
      Yoshiro Tahara, Kazunari Akiyoshi
    • Journal Title

      Encyclopedia of polymeric nanomaterials

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Presentation] ナノゲル架橋マイクロスフェアの開発と評価2013

    • Author(s)
      田原義朗,向井貞篤,澤田晋一,秋吉一成
    • Organizer
      第1回バイオ関連化学シンポジウム若手フォーラム
    • Place of Presentation
      名古屋(P-36, ポスター発表)
    • Year and Date
      2013-09-26
    • Related Report
      2013 Final Research Report
  • [Presentation] エマルション内架橋プロセスによるナノゲル架橋マイクロスフェアの開発2013

    • Author(s)
      田原義朗,向井貞篤,澤田晋一,秋吉一成
    • Organizer
      化学工学会第45回秋季大会
    • Place of Presentation
      岡山(D105, 口頭発表)
    • Related Report
      2013 Final Research Report
  • [Presentation] ナノゲル架橋マイクロスフェアの開発と評価2013

    • Author(s)
      田原義朗
    • Organizer
      第1回バイオ関連化学シンポジウム若手フォーラム
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] エマルション内架橋プロセスによるナノゲル架橋マイクロスフェアの開発2013

    • Author(s)
      田原義朗
    • Organizer
      化学工学会第45回秋季大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] Raspberry-like hybrid gel particles prepared by bottom-up method of nanogels as a novel material for drug delivery system2013

    • Author(s)
      Yoshiro Tahara
    • Organizer
      16th International Symposium on Recent Advances in Drug Delivery Systems
    • Place of Presentation
      Salt lake city (UT, USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Raspberry-like hybrid gel particles by bottom-up method of nanogels for biomedical application2012

    • Author(s)
      Yoshiro Tahara
    • Organizer
      9th International Gel symposium - Gelsympo 2012 -
    • Place of Presentation
      Tsukuba (Japan)
    • Related Report
      2012 Annual Research Report
  • [Book] ナノゲル基盤材料によるタンパク質医薬の徐放技術とその応用 (遺伝子医学MOOK別冊–ここまで広がるドラッグ徐放技術の最前線–,第2章-2)2013

    • Author(s)
      田原義朗,秋吉一成
    • Related Report
      2013 Final Research Report
  • [Book] 遺伝子医学MOOK別冊 ここまで広がるドラッグ徐放技術の最前線2013

    • Author(s)
      田原義朗, 秋吉一成
    • Total Pages
      3
    • Publisher
      メディカルドゥ
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.jst.go.jp/erato/akiyoshi/index.html

    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] ナノゲル架橋ゲル粒子の調製と応用2013

    • Inventor(s)
      秋吉一成, 田原義朗, 向井貞篤, 澤田晋一
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-072258
    • Filing Date
      2013-03-29
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Overseas

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Published: 2012-11-27   Modified: 2019-07-29  

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