Effect of placental serotonin exposure on lipid metabolism of skeletal muscles

Research Project

Project/Area Number	24870008
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Animal physiology/Animal behavior
Research Institution	University of the Ryukyus
Principal Investigator	KONNO Toshihiro 琉球大学, 農学部, 准教授 (60568260)
Project Period (FY)	2012-08-31 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	骨格筋 / 脂質代謝 / 胎盤 / セロトニン
Research Abstract	Skeletal muscles are composed of muscle fibers, which are classified into red muscle fibers and white muscle fibers, depending upon their energy metabolisms. The red muscle fibers utilize fat as an energy source, while the white muscle fibers utilize glucose. The composition of muscle fiber types determines the muscle's metabolic property. Differentiation of immature fibers require proper innervation. In mice, placenta contributes to the fetal serotonin nerve development an an external source of serotonin. In this study, we investigated the effect of placental serotonin on the neonatal growth and the composition of muscle fiber types. The inhibition of placental serotonin synthesis did not affect on the neonatal growth. Also, the muscle fiber composition did not differ between pups from control and serotonin synthesis inhibition groups. Our results indicated that the placental serotonin had only limited effect in determination of metabolic property of skeletal muscles.