| Project/Area Number |
24870008
|
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 骨格筋 / 脂質代謝 / 胎盤 / セロトニン |
|---|
| Research Abstract |
Skeletal muscles are composed of muscle fibers, which are classified into red muscle fibers and white muscle fibers, depending upon their energy metabolisms. The red muscle fibers utilize fat as an energy source, while the white muscle fibers utilize glucose. The composition of muscle fiber types determines the muscle's metabolic property. Differentiation of immature fibers require proper innervation. In mice, placenta contributes to the fetal serotonin nerve development an an external source of serotonin. In this study, we investigated the effect of placental serotonin on the neonatal growth and the composition of muscle fiber types. The inhibition of placental serotonin synthesis did not affect on the neonatal growth. Also, the muscle fiber composition did not differ between pups from control and serotonin synthesis inhibition groups. Our results indicated that the placental serotonin had only limited effect in determination of metabolic property of skeletal muscles.
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