Characterization of condensin-mediated DNA damage response in plants
| Project/Area Number |
24870026
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Plant molecular biology/Plant physiology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
SAKAMOTO Takuya 東京理科大学, 理工学部, ポストドクトラル研究員 (40637691)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | シロイヌナズナ / コンデンシンII / 染色体配置 / DNA損傷 / コンデンシン / オーロラキナーゼ |
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| Research Abstract |
A plant chromosomal protein complex, condensin II, is known to function in alleviating DNA damage. However, it is still unclear that how condensin II acts in DNA damage response. To reveal the detailed function of condensin II in the alleviation of DNA damage, we characterized Arabidopsis condensin II mutants. As a result, it was found that Arabidopsis condensin II is unlikely to be required for the DNA damage repair but functions in the high compaction of genome-wide chromatin. These findings indicate that Arabidopsis condensin II is considered to physically protect DNA through the high compaction of chromatin.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] New insights into the dynamics of plant cell nuclei and chromosomes2013
Author(s)
Matsunaga, S., Katagiri, Y., Nagashima, Y., Sugiyama, T., Hasegawa, J., Hayashi, K. and Sakamoto, T.
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Journal Title
INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY
Volume: 305
Pages: 253-301
DOI
Related Report
Peer Reviewed
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