| Project/Area Number |
24870032
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | Microbial Chemistry Research Foundation |
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Principal Investigator |
SATOH Ryosuke 公益財団法人微生物化学研究会, 微生物化学研究所, 博士研究員 (00635592)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | IRES / 翻訳開始機構 / ポリオウイルス / 組織特異性 / 宿主因子 |
|---|
| Research Abstract |
Poliovirus (PV) infection occurs as a result of destruction of motor neurons in the central nervous system (CNS). The aim of this study is to elucidate the fundamental process of IRES-dependent translational initiation involved in PV tissue tropism, through the identification and functional analysis of the host factors that regulate PV IRES (internal ribosome entry sites)-dependent translational initiation. In this study, we identified some host factor candidates that are specifically expressing and acting in nerve cells, utilizing biochemical/analytical chemical screening systems. This study is valuable to reveal the molecular basis of acquiring the CNS-specificity of PV infection through IRES-dependent translation.
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