Research Project
Grant-in-Aid for Research Activity Start-up
Autophagy is one of the intracellular protein degradation system that is implicated in elimination of denatured proteins and infectious microbes. It is expected that inhibition of autophagy is cause of West Nile encephalomyelitis. In this study, we found that autophagy was inhibited by NS2B/3 that is non-structural proteins of WNV. We also found autophagy inhibited West Nile virus replication at the viral genome replication and gene expression stages.
All 2014 2013 2012
All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (13 results)
ACS Nano
Volume: 7(5) Issue: 5 Pages: 3926-3938
10.1021/nn3057005
PLoS One
Volume: 8(10) Issue: 10 Pages: e76668-e76668
10.1371/journal.pone.0076668
120005350093
J Gen Virol.
Volume: 94(Pt 6) Issue: 6 Pages: 1357-64
10.1099/vir.0.050740-0
Mol Biosyst.
Volume: 9(3) Issue: 3 Pages: 501-507
10.1039/c2mb25420d