| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We found that Cry1 and Cry2 are not essential for the circadian rhythm generation in the SCN cells, and are necessary for the development of intercellular networks in the adult SCN (Ono et al Nat. Commun. 2013). We also found that neonatal exposure to constant light compensates CRY functions for the disruption of circadian behavioral rhythms under constant dark (Ono et al PLOS ONE. 2013).
In order to understand the role of VIP signaling in the CryDKO SCN during development, CryDKO mice were bred with VIP receptor (VPAC2) KO mice. We measured PER2::LUC bioluminescence in the SCN from CryDKO-VPAC2KO mice.
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