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Molecular mechanisms of the cellular coupling in the SCN during postnatal development

Research Project

Project/Area Number 24890001
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionHokkaido University

Principal Investigator

ONO Daisuke  北海道大学, 医学(系)研究科(研究院), 特任助教 (30634224)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords概日リズム / 視交叉上核 / 時計遺伝子 / 生後発達 / 光イメージング / 発光イメージング / サーカディアンリズム / 生物発光
Research Abstract

We found that Cry1 and Cry2 are not essential for the circadian rhythm generation in the SCN cells, and are necessary for the development of intercellular networks in the adult SCN (Ono et al Nat. Commun. 2013). We also found that neonatal exposure to constant light compensates CRY functions for the disruption of circadian behavioral rhythms under constant dark (Ono et al PLOS ONE. 2013).
In order to understand the role of VIP signaling in the CryDKO SCN during development, CryDKO mice were bred with VIP receptor (VPAC2) KO mice. We measured PER2::LUC bioluminescence in the SCN from CryDKO-VPAC2KO mice.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (43 results)

All 2014 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (19 results) (of which Invited: 3 results) Book (12 results) Remarks (5 results)

  • [Journal Article] Postnatal Constant Light Compensates Cryptochrome1 and 2 Double Deficiency for Disruption of Circadian Behavioral Rhythms in Mice under Constant Dark2013

    • Author(s)
      Ono D, Honma S and Honma K
    • Journal Title

      PLoS One

      Volume: 8(11) Issue: 11 Pages: 380615-380615

    • DOI

      10.1371/journal.pone.0080615

    • NAID

      120005348969

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus2013

    • Author(s)
      Ono D, Honma S, and Honma K
    • Journal Title

      Nat. Comm

      Volume: (in press) Issue: 1 Pages: 1666-1666

    • DOI

      10.1038/ncomms2670

    • NAID

      120005343762

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oscillator cell networks in the hypothalamic suprachiasmatic nucleus, the mammalian circadian clock2013

    • Author(s)
      S. Honma, D. Ono, K.-I. Honma
    • Journal Title

      In Advances in Cognitive Neurodynamics (III), Y.Yamaguchi ed. Springer, Tokyo

      Pages: 185-190

    • DOI

      10.1007/978-94-007-4792-0_25

    • ISBN
      9789400747913, 9789400747920
    • Related Report
      2013 Final Research Report
  • [Journal Article] Topological specificity and hierarchical network of the circadian calcium rhythm in the suprachiasmatic nucleus2012

    • Author(s)
      Enoki R, Kuroda S, Ono C, Hasan MT, Honma S, Ueda T and Honma K
    • Journal Title

      Proc.Natl. Acad.Sci USA

      Volume: 109 Issue: 52 Pages: 21498-21503

    • DOI

      10.1073/pnas.1214415110

    • NAID

      120005295647

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single-cell resolution fluorescence imaging of circadian rhythms detected with a Nipkow spinning disk confocal system.2012

    • Author(s)
      Enoki R. et al.
    • Journal Title

      J Neurosci Methods

      Volume: 202 Issue: 1 Pages: 72-79

    • DOI

      10.1016/j.jneumeth.2012.03.004

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] JNK regulates the photic response of the mammalian circadian clock2012

    • Author(s)
      Yoshitane, H., Honma, S., Fukada, Y., 他11名、6番目
    • Journal Title

      EMBO Rep.

      Volume: (印刷中) Issue: 5 Pages: 455-461

    • DOI

      10.1038/embor.2012.37

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] De novo synthesis of PERIOD initiates circadian oscillation in cultured mouse suprachiasmatic nucleus after prolonged inhibition of protein synthesis by cycloheximide2012

    • Author(s)
      Nishide, S.Y., Ono, D., Yamada, Y., Honma, S., Honma, K.
    • Journal Title

      Eur.J.Neurosci.

      Volume: 35 Issue: 2 Pages: 291-299

    • DOI

      10.1111/j.1460-9568.2011.07952.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 概日時計中枢、視交叉上核におけるリズム形成とその調節機構2014

    • Author(s)
      小野大輔、本間さと、本間研一
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Developmental changes of coherent circadian rhythms in the SCN of Cryptochrome deficient mice2013

    • Author(s)
      Ono, D., Honma, S., and Honma, K
    • Organizer
      Gordon research seminar
    • Place of Presentation
      Newport, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Developmental changes of coherent circadian rhythms in the SCN of Cryptochrome deficient mice2013

    • Author(s)
      Ono, D., Honma, S., and Honma, K
    • Organizer
      Gordon research conference
    • Place of Presentation
      Newport, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] In vivo measurement of circadian gene expression rhythms in the suprachiasmatic nucleus in freely moving mice2013

    • Author(s)
      Ono, D., Honma, K., and Honma, S
    • Organizer
      The 11th international symposium for future drug discovery and medical care
    • Place of Presentation
      Sapporo
    • Related Report
      2013 Final Research Report
  • [Presentation] 視交叉上核の生後発達と細胞間カップリング2013

    • Author(s)
      小野大輔、本間さと、本間研一
    • Organizer
      第20回日本時間生物学会
    • Place of Presentation
      近畿大学
    • Related Report
      2013 Final Research Report
  • [Presentation] CRYPTOCHROMEは生後発達における視交叉上核の概日リズムの細胞間カップリングに重要である2013

    • Author(s)
      小野大輔、本間さと、本間研一
    • Organizer
      Neuro2013
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 光ファイバーを用いた無麻酔・無拘束マウス視交叉上核からの長期発光測定2013

    • Author(s)
      小野大輔、本間さと、本間研一
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Developmental changes of coherent circadian rhythms in the SCN of Cryptochrome deficient mice.2013

    • Author(s)
      Ono, D., Honma, S., and Honma, K.
    • Organizer
      Gordon research seminar
    • Place of Presentation
      Salve Regina University, Newport
    • Related Report
      2013 Annual Research Report
  • [Presentation] Developmental changes of coherent circadian rhythms in the SCN of Cryptochrome deficient mice.2013

    • Author(s)
      Ono, D., Honma, S., and Honma, K.
    • Organizer
      Gordon research conference
    • Place of Presentation
      Salve Regina University, Newport
    • Related Report
      2013 Annual Research Report
  • [Presentation] In vivo measurement of circadian gene expression rhythms in the suprachiasmatic nucleus in freely moving mice.2013

    • Author(s)
      Ono, D., Honma, K., and Honma, S.
    • Organizer
      The 11th international symposium for future drug discovery and medical care.
    • Place of Presentation
      北海道大学、札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 視交叉上核の生後発達と細胞間カップリング2013

    • Author(s)
      小野大輔、本間さと、本間研一
    • Organizer
      第20回日本時間生物学会
    • Place of Presentation
      近畿大学、東大阪市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] CRYPTOCHROME は生後発達における視交叉上核の概日リズムの細胞間カップリングに重要である2013

    • Author(s)
      小野大輔、本間さと、本間研一
    • Organizer
      Neuro2013
    • Place of Presentation
      国立京都国際会館、京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] CRYPTOCHROME は生後発達における視交叉上核の概日リズムの細胞間カップリングに重要である2013

    • Author(s)
      小野 大輔
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Developmental changes of coherent circadian rhythms in the SCN of Cryptochrome deficient mice2013

    • Author(s)
      Daisuke Ono
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Salve Regina University in Newport (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 概日時計の生後発達と時計遺伝子Cryptochrome2012

    • Author(s)
      小野大輔、本間さと、本間研一
    • Organizer
      第92回日本生理学会北海道地方会9
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-01
    • Related Report
      2013 Final Research Report
  • [Presentation] In vivo monitoring of circadian gene expression rhythms with an optic fiber in freely moving mice2012

    • Author(s)
      Ono, D., Honma, S., and Honma, K
    • Organizer
      International symposium and workshop on frontiers in sleep and biological rhythms research
    • Place of Presentation
      Izmir
    • Related Report
      2013 Final Research Report
  • [Presentation] 中枢時計の発達と時計遺伝子機能2012

    • Author(s)
      小野大輔、本間さと、本間研一
    • Organizer
      第19回日本時間生物学会学術大会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Cry1/Cry2ダブルノックアウトマウス視交叉上核の概日リズムの生後発達2012

    • Author(s)
      小野大輔、本間さと、本間研一
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 中枢時計の発達と時計遺伝子機能2012

    • Author(s)
      小野 大輔
    • Organizer
      第19回日本時間生物学会学術大会
    • Place of Presentation
      北海道大学(札幌)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Cellular oscillators in the suprachiasmatic nucleus for behavior rhythm expression in the mouse lacking CRYPTOCHROME. In : Honma K. ed2014

    • Author(s)
      Honma S, Ono D and Honma K
    • Publisher
      Dynamics of Circadian Oscillation in the SCN, Hokkaido Univ(Press)
    • Related Report
      2013 Final Research Report
  • [Book] Cellular circadian rhythms in the suprachiasmatic nucleus : An oscillatory or a stochastic process? In : Honma K. ed2014

    • Author(s)
      Ono D, Kori H, Honma S, Daan S and Honma K
    • Publisher
      Dynamics of Circadian Oscillation in the SCN, Hokkaido Univ(Press)
    • Related Report
      2013 Final Research Report
  • [Book] Bout Oscillator : hypothetical circadian oscillators for activity bouts. In : Honma K. ed2014

    • Author(s)
      Honma K, Ono D, Honma S and Tokuda I
    • Publisher
      Dynamics of Circadian Oscillation in the SCN, Hokkaido Univ(Press)
    • Related Report
      2013 Final Research Report
  • [Book] Oscillator Network modeling of the suprachiasmatic nucleus in Cry1/Cry2 double deficient mice. In : Honma K. ed2014

    • Author(s)
      Tokuda I, Herzel H, Ono D, Honma S and Honma K
    • Publisher
      Dynamics of Circadian Oscillation in the SCN, Hokkaido Univ(Press)
    • Related Report
      2013 Final Research Report
  • [Book] 時計遺伝子Cryptochromeは生後発達に伴う視交叉上核の概日リズム形成に重要な役割を示す(Best article of the year)2014

    • Author(s)
      小野大輔、本間さと、本間研一
    • Publisher
      北海道医学雑誌(in press)
    • Related Report
      2013 Final Research Report
  • [Book] Dynamics of Circadian Oscillation in the SCN2014

    • Author(s)
      Ono, D., Kori, H., Honma, S., Daan, S., Honma, K.
    • Publisher
      北海道出版会
    • Related Report
      2013 Annual Research Report
  • [Book] Dynamics of Circadian Oscillation in the SCN2014

    • Author(s)
      Honma, S., Ono, D., Honma, K.
    • Publisher
      北海道出版会
    • Related Report
      2013 Annual Research Report
  • [Book] 北海道医学雑誌2014

    • Author(s)
      小野大輔、本間さと、本間研一
    • Publisher
      北海道医学会
    • Related Report
      2013 Annual Research Report
  • [Book] 生体リズムの分子機構,最新臨床睡眠学、66巻増刊号、東京2013

    • Author(s)
      小野大輔、本間研一、本間さと
    • Publisher
      日本臨床社
    • Related Report
      2013 Final Research Report
  • [Book] 最新臨床睡眠学2013

    • Author(s)
      小野大輔、本間さと、本間研一
    • Total Pages
      768
    • Publisher
      日本臨床
    • Related Report
      2013 Annual Research Report
  • [Book] 最新臨床睡眠学2013

    • Author(s)
      小野 大輔
    • Publisher
      日本臨床社
    • Related Report
      2012 Annual Research Report
  • [Book] Advances in Cognitive Neurodynamics (III)2013

    • Author(s)
      Sato Honma
    • Publisher
      Springer
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.hokudai.ac.jp/news/131121_pr_med.pdf

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.hokudai.ac.jp/news/130412_pr_med.pdf

    • Related Report
      2013 Final Research Report
  • [Remarks] 幼少期の光で,遺伝性概日リズム障害を克服

    • URL

      http://www.hokudai.ac.jp/news/131121_pr_med.pdf

    • Related Report
      2013 Annual Research Report
  • [Remarks] 遺伝性リズム障害の原因を解明

    • URL

      http://www.hokudai.ac.jp/news/130412_pr_med.pdf

    • Related Report
      2013 Annual Research Report
  • [Remarks] プレスリリース:遺伝性リズム障害の原因を解明

    • URL

      http://www.hokudai.ac.jp/news/130412_pr_med.pdf

    • Related Report
      2012 Annual Research Report

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Published: 2012-11-27   Modified: 2023-03-16  

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