| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
In this study, we evaluated the relationship of the biomolecules (Fatty acid-binding protein 5 (FABP5) and Thrombospondin-4 (TSP4)) detected by proteomics analysis to the progression of atherosclerotic state, and developed a novel imaging probe " 99mTc-HVPA" for early diagnosis of vulnerable plaque. FABP5 showed higher expression in Type IV legion (AHA classification) in the vessels of atherosclerotic model mice (ApoE -/- mice) and in the inflammatory (M1) macrophages. Furtheremore, we suceeded to developed 99mTc-HVPA which targeted to TSP4, and found that 99mTc-HVPA had a basic property as a SPECT imaging probe for diagnosis of vulnerable plaque.
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