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Effect of bone metabolism hormone on osteoclast differentiation niche of pre-osteoblast

Research Project

Project/Area Number 24890005
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionHokkaido University

Principal Investigator

YAMADA tamaki  北海道大学, 歯学研究科(研究院), 助教 (80580943)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords前骨芽細胞
Research Abstract

We have investigated niche of pre-osteoblasts network about differentiation of osteoclasts using micromorphology and histochemical methods. We were performed by means of bone metastasis of breast cancer model. The sections of femur with osteolysis lesions indicated that metastatic breast cancer cells filled the bone marrow cavity and that numerous TRAP-positive multinucleated osteoclasts and ALP-positive osteoblasts aligned along the surface of the cortical bone. Furthermore, in this study, we focused attention on osteocytes which remained poorly understood. In osteocytes-derived factors, both sclerostin and FGF23, immunohistochemical examination revealed that these facors showed weak expression in osteocytes adjacent to bone metastases compared with those adjacent to bone marrow. This result that osteocyte was affected by cancer cells in bone metastasis foci.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (4 results)

All 2013

All Presentation (4 results)

  • [Presentation] 乳癌骨転移巣における骨細胞産生因子の組織化学的解析2013

    • Author(s)
      山田珠希
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山コンベンションセンター(岡山県)
    • Related Report
      2013 Final Research Report
  • [Presentation] 乳癌骨転移巣における骨細胞産生因子の組織学的解析2013

    • Author(s)
      山田珠希
    • Organizer
      第67回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      栃木県総合文化センター(栃木県)
    • Related Report
      2013 Final Research Report
  • [Presentation] 乳癌骨転移巣における骨細胞産生因子の組織学的解析2013

    • Author(s)
      山田珠希
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山県(岡山コンベンションセンター)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 乳癌骨転移巣における骨細胞産生因子の組織学的解析2013

    • Author(s)
      山田 珠希
    • Organizer
      第67回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      栃木県総合文化センター
    • Related Report
      2012 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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