| Project/Area Number |
24890006
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Hokkaido University |
|---|
Principal Investigator |
SAEKI Ayumi 北海道大学, 歯学研究科(研究院), 助教 (70638345)
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|---|
| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | インフラマソーム / 口腔連鎖球菌 / 口腔レンサ球菌 |
|---|
| Research Abstract |
S. mutans, S. gordonii and S. sanguinis, as extracellular pathogens, which are normal inhabitants of the human oral cavity, induced IL-1b production by the dendritic cell line XS-106 cells derived from A/J mice in dose-dependent manners. The activity of S. sanguinis to induce IL-1b production was dependent on caspases-1 and NLRP3. Thus, this study suggests that oral streptococci activate NLRP3 inflammasome to produce IL-1b in murine dendritic cells.
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