New function of LPA3 receptor that regulates vagal afferent nerves activation
Project/Area Number |
24890014
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Medical pharmacy
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Research Institution | Tohoku University |
Principal Investigator |
KANO KUNIYUKI 東北大学, 薬学研究科(研究院), 助教 (50636404)
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Project Period (FY) |
2012-08-31 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | リゾホスファチジン酸 / 虚血性心疾患 / LPA3 / 迷走神経 |
Research Abstract |
In this study, we assessed the functional effects of LPA3 signal-induced vagal excitation and quantifying LPA and other lysophospholipids level in myocardial infarction. We found that injection of LPA3 agonist named T13, which is 2-acyl LPA analog, significantly decreased infact area in acute ischemic injury model. We analyzed clinical specimen (plasma) from acute coronary syndrome (ACS) patients by LC-MS/MS, and found unsaturated LPA, which show potent agonist activity for LPA3, were selectively elevated in ACS. In addition, other unsaturated lysophospholipids (LPC, LPE, LPG, LPI, LysoPS) were also increased. These results suggest that unsaturated LPA are produced by increased substrates of autotaxin in myocardial infarction.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo2014
Author(s)
Nakanaga K, Hama K, Kano K, Sato T, Yukiura H, Inoue A, Saigusa D, Tokuyama H, Tomioka Y, Nishina H, Kawahara A, Aoki J
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Journal Title
J. Biochem
Volume: 155
Issue: 4
Pages: 235-241
DOI
Related Report
Peer Reviewed / Open Access
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