Identification of microRNAs that regulate differentiation of human lung progenitor cells
| Project/Area Number |
24890016
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
FUJINO Naoya 東北大学, 医学(系)研究科(研究院), 非常勤講師 (10633670)
|
|---|
| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 組織幹細胞 / 自己複製 / 分化 / 肺上皮前駆細胞 / マイクロRNA / 上皮間葉移行 / 修復 / 肺胞上皮前駆細胞 / II型肺胞上皮細胞 / microRNA |
|---|
| Research Abstract |
Tissue-specific stem/progenitor cells have the ability to self-renew and the potential to differentiate into multiple cell-types and have a role in homeostasis and repair. The aim of this study was to identify microRNA (miRNA) that regulate function of human lung progenitor cells. We found that expression of miR-200c was inhibited in human lung progenitor cells compared with human mature alveolar epithelial cells. Transfection of a synthetic RNA, which mimics miR-200c, suppressed proliferation in human lung progenitor cells. This suggests that the genes targeted by miR-200c regulate growth of human lung progenitor cells.
|
Report
(3 results)
Research Products
(2 results)
-
[Journal Article] Increased severity of H1N1 pandemic influenza virus infection in alveolar type II cells from patients with pulmonary fibrosis2013
Author(s)
Fujino N, Kubo H, Ota C, Suzuki T, Takahashi T, Yamada M, Suzuki S, Kondo T, Nagatomi R, Tando Y, Yamaya M
-
Journal Title
J Infect Dis
Volume: 207
Pages: 692-692
Related Report
Peer Reviewed
-
