Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Research Abstract |
Tissue-specific stem/progenitor cells have the ability to self-renew and the potential to differentiate into multiple cell-types and have a role in homeostasis and repair. The aim of this study was to identify microRNA (miRNA) that regulate function of human lung progenitor cells. We found that expression of miR-200c was inhibited in human lung progenitor cells compared with human mature alveolar epithelial cells. Transfection of a synthetic RNA, which mimics miR-200c, suppressed proliferation in human lung progenitor cells. This suggests that the genes targeted by miR-200c regulate growth of human lung progenitor cells.
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