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The effect of NMO-IgG and complement against primary human astrocytes in culture.

Research Project

Project/Area Number 24890017
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionTohoku University

Principal Investigator

NISHIYAMA Shuhei  東北大学, 大学病院, 医員 (60636017)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords視神経脊髄炎 / アストロサイト / 補体介在性障害 / 補体非介在性障害 / 補体介在性傷害 / 補体非介在性傷害
Research Abstract

Purified IgG derived from anti-Aquaporin 4(AQP4) antibody positive patients(NMO-IgG) itself caused AQP4 cluster on astrocytic membrane following endocytosis. NMO-IgG also caused reversible morphological changes like shrinking of foot processes and adhesion ability. NMO-IgG with human complements irreversibly damage the cells in a short time, suggesting a unique AQP4 antibody-mediated astrocytopathy in NMO.
Complement is involved in the pathogenesis of NMO, and the worn-out of complement regulatory proteins like CD55 or CD59 on the membrane accelerate astrocytic cytotoxicity. The controlling of complement or complement regulatory proteins may be a new therapeutic target in NMO.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (11 results)

All 2013 Other

All Journal Article (2 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] 視神経脊髄炎(NMO)におけるアストロサイトの役割2013

    • Author(s)
      西山修平、三須建郎、中島一郎、藤原一男
    • Journal Title

      神経内科

      Volume: 79(2) Pages: 257-61

    • Related Report
      2013 Final Research Report
  • [Journal Article] 視神経脊髄炎(NMO)におけるアストロサイトの役割2013

    • Author(s)
      西山修平、三須建郎、中島一郎、藤原一男
    • Journal Title

      神経内科

      Volume: 第79巻第2号 Pages: 257-261

    • Related Report
      2013 Annual Research Report
  • [Presentation] 炎症性脱髄性疾患の診断・予後における髄液中GFAP濃度有用性の多施設横断的検討2013

    • Author(s)
      西山修平、三須建郎、清水優子、横山和正、景山卓、高井良樹、高野里菜、高橋利幸、藤盛寿一、佐藤滋、中島一郎、糸山泰人、藤原一男、青木正志
    • Organizer
      第25回日本神経免疫学会学術集会
    • Place of Presentation
      下関
    • Related Report
      2013 Final Research Report
  • [Presentation] A multicentric cross-sectional study of the usefulness of CSF-GFAP in the diagnosis and the prognosis of inflammatory demyelinating diseases2013

    • Author(s)
      S. Nishiyama, T. Misu, Y. Simizu, K. Yokoyama, T. Kageyama, Y. Takai, R. Takano, T. Takahashi, J. Fujimori, S. Sato, I. Nakashima, Y. Itoyama, K. Fujihara, M. Aoki
    • Organizer
      PACTRIMS 2013
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] A multicentric cross-sectional study of the usefulness of CSF-GFAP in the diagnosis and the prognosis of inflammatory demyelinating diseases2013

    • Author(s)
      S. Nishiyama, T. Misu, Y. Simizu, K. Yokoyama, T. Kageyama, Y. Takai, R. Takano, T. Takahashi, J. Fujimori, S. Sato, I. Nakashima, Y. Itoyama, K. Fujihara, M. Aoki
    • Organizer
      29th ECTRIMS
    • Place of Presentation
      デンマーク・コペンハーゲン
    • Related Report
      2013 Final Research Report
  • [Presentation] 炎症性脱髄性疾患の診断・予後における髄液中GFAP濃度有用性の多施設横断的検討2013

    • Author(s)
      西山修平、三須建郎、清水優子、横山和正、景山卓、高井良樹、高野里菜、高橋利幸、藤盛寿一、佐藤滋、中島一郎、糸山泰人、藤原一男、青木正志
    • Organizer
      第54回日本神経学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 炎症性脱髄性疾患の診断・予後における脳脊髄液中GFAP 濃度有用性の多施設横断的検討2013

    • Author(s)
      西山修平、三須建郎、清水優子、横山和正、景山卓、高井良樹、高野里菜、高橋利幸、藤盛寿一、佐藤滋、中島一郎、糸山泰人、藤原一男、青木正志
    • Organizer
      第54回日本神経学会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] A multicentric cross-sectional study of the usefulness of cerebrospinal fluid-glial fibrillary acidic protein (CSF-GFAP) in the diagnosis and prognosis of inflammatory demyelinating diseases2013

    • Author(s)
      S. Nishiyama, T. Misu, Y. Simizu, K. Yokoyama, T. Kageyama, Y. Takai, R. Takano, T. Takahashi, J. Fujimori, S. Sato, I. Nakashima, Y. Itoyama, K. Fujihara, M. Aoki
    • Organizer
      29th ECTRIMS
    • Place of Presentation
      デンマーク・コペンハーゲン
    • Related Report
      2013 Annual Research Report
  • [Presentation] A multicenter, cross-sectional study of the usefulness of CSF-GFAP in the diagnosis and the prognosis of inflammatory CNS diseases.2013

    • Author(s)
      S. Nishiyama, T. Misu, Y. Simizu, K. Yokoyama, T. Kageyama, Y. Takai, R. Takano, T. Takahashi, J. Fujimori, S. Sato, I. Nakashima, Y. Itoyama, K. Fujihara, M. Aoki
    • Organizer
      PACTRIMS 2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 炎症性脱髄性疾患の診断・予後における脳脊髄液中GFAP 濃度有用性の多施設横断的検討2013

    • Author(s)
      西山修平、三須建郎、清水優子、横山和正、景山卓、高井良樹、高野里菜、高橋利幸、藤盛寿一、佐藤滋、中島一郎、糸山泰人、藤原一男、青木正志
    • Organizer
      第25回日本神経免疫学会学術集会
    • Place of Presentation
      下関
    • Related Report
      2013 Annual Research Report
  • [Remarks] 研究内容

    • URL

      http://www.ms.med.tohoku.ac.jp/research.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2012-11-27   Modified: 2019-07-29  

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