| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Purified IgG derived from anti-Aquaporin 4(AQP4) antibody positive patients(NMO-IgG) itself caused AQP4 cluster on astrocytic membrane following endocytosis. NMO-IgG also caused reversible morphological changes like shrinking of foot processes and adhesion ability. NMO-IgG with human complements irreversibly damage the cells in a short time, suggesting a unique AQP4 antibody-mediated astrocytopathy in NMO.
Complement is involved in the pathogenesis of NMO, and the worn-out of complement regulatory proteins like CD55 or CD59 on the membrane accelerate astrocytic cytotoxicity. The controlling of complement or complement regulatory proteins may be a new therapeutic target in NMO.
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