The study of swallowing disorder in neuromuscular disease mice model

• Project/Area Number: 24890021
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Tohoku University
• Principal Investigator: SATO TADASU 東北大学, 歯学研究科(研究院), 助教 (40637964)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 神経筋疾患 / 嚥下障害

Research Abstract

The cause of muscle atrophy disease includes degeneration of nerves and/or muscles. The swallowing disorder is known to be derived from such disease.
In this study, we examined the distribution and origin of sensory nerves in the pharynx. We also examined the neural degeneration in neuromuscular disease mice model.

Research Products

• [Journal Article] Prednisolone induces microglial activation in the subnucleus caudalis of the rat trigeminal sensory complex. (2014)
  • Author(s): Y. Endo,N.Shoji,Y.Shimada,E.Kasahara,M.Iikubo,T.Sato,T.Sasano,H.Ichikawa
  • Journal Title: Cell Mol Neurobiol Volume: 34 Issue: 1 Pages: 95-100
  • DOI: 10.1007/s10571-013-9990-z
  • Peer Reviewed
• [Journal Article] The distribution of galanin - immunoreactive nerve fibers in the rat pharynx (2013)
  • Author(s): Toshihiko Suzuki, Tadasu Sato, Mitsuhiro Kano and Hiroyuki Ichikawa
  • Journal Title: Neuropeptides Volume: 47(4) Issue: 4 Pages: 231-236
  • DOI: 10.1016/j.npep.2013.05.001
  • Peer Reviewed
• [Journal Article] The distribution of TRPV1 and TRPV2 in the rat pharynx (2013)
  • Author(s): Sasaki R., Ichikawa H. et al
  • Journal Title: Cell Mol Neurobiol Volume: 33 巻 Issue: 5 Pages: 707-714
  • DOI: 10.1007/s10571-013-9938-3
  • Peer Reviewed
• [Journal Article] The distribution of transient receptor potential melastatin-8in the rat soft palate, epiglottis, and pharynx. (2013)
  • Author(s): Sato T, Fujita M, Kano M, Hosokawa H, Kondo T, Suzuki T, Kasahara E, Shoji N, Sasano T, Ichikawa H.
  • Journal Title: Cell Mol Neurobiol Volume: 33 Issue: 2 Pages: 161-5
  • DOI: 10.1007/s10571-012-9888-1
  • Peer Reviewed
• [Journal Article] Osteocalcin - and Osteopontin - Containing Neurons in the Rat Hind Brain (2012)
  • Author(s): Toshihiko Suzuki, Tadasu Sato and Hiroyuki Ichikawa
  • Journal Title: Cellular and Molecular Neurobiology Volume: 32(8) Issue: 8 Pages: 1265-1273
  • DOI: 10.1007/s10571-012-9851-1
  • Peer Reviewed
• [Presentation] ラット咽頭及びその周囲組織におけるTRPV1とTRPV2の分布 (2013)
  • Author(s): 佐藤匡、矢島健大、狩野充浩、鈴木敏彦、市川博之
  • Organizer: 第55回歯科基礎医学会学術大会・総会
  • Place of Presentation: 岡山
• [Presentation] ラット軟口蓋、喉頭蓋及び咽頭におけるTRPM8, TRPV1, TRPV2の分布 (2013)
  • Author(s): 佐藤匡、佐々木里香、藤田雅俊、狩野充浩、澤浦亮平、鈴木敏彦、市川博之
  • Organizer: 日本解剖学会第59回東北・北海道連合支部学術集会
  • Place of Presentation: 札幌
• [Presentation] The distribution of TRPV1 and TRPV2 in the rat pharynx (2013)
  • Author(s): Tadasu Sato, Rika Sasaki, Mitsuhiro Kano, Toshihiko Suzuki, and Hiroyuki Ichikawa
  • Organizer: ASahct2013 International of Symposium Anatomical Science for advance in health and clinical therapy
  • Place of Presentation: 仙台
• [Presentation] ラット軟口蓋、喉頭蓋及び咽頭におけるTRPM8,TRPV1,TRPV2の分布 (2013)
  • Author(s): 佐藤 匡、佐々木 里香、藤田 雅俊、狩野 充浩、澤浦 亮平、鈴木 敏彦、市川 博之
  • Organizer: 日本解剖学会 第59回東北・北海道連合支部学術集会
  • Place of Presentation: 北海道大学 大学院獣医学研究科
• [Presentation] ラット咽頭及びその周囲組織におけるTRPV1とTRPV2の分布 (2013)
  • Author(s): 佐藤匡 、矢島健大、狩野充浩、鈴木敏彦、市川博之
  • Organizer: 第55回歯科基礎医学会学術大会・総会
  • Place of Presentation: 岡山コンベンションセンター
• [Presentation] 喉頭蓋及び咽頭におけるTRPM8の分布 (2012)
  • Author(s): 佐藤匡、藤田雅俊、狩野充浩、鈴木敏彦、市川博之
  • Organizer: 第54回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 郡山
• [Presentation] Dmuマウスにおける骨格筋及び運動ニューロンの変性 (2012)
  • Author(s): 藤田雅俊、佐藤匡、狩野充浩、清水良央、金高弘恭、鈴木敏彦、市川博之
  • Organizer: 第54回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 郡山