| Project/Area Number |
24890024
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SUGAWARA Yu 東北大学, 大学病院, 医員 (00636954)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯髄幹細胞 / オリゴデンドロサイト / PDGF / 再生 / 歯 |
|---|
| Research Abstract |
PDGF-AA promotes dental pulp stem cell differentiation into odontoblast, whereas PDGF-BB promotes proliferation and differentiation of dental pulp stem cell into oligodendrocyte via PDGFRb-ERK1/2 and Akt pathway. Further, PDGF-BB inhibits BMP2 induced dental pulp stem cells differentiation into odontoblast inhibiting Smad5 phosphorylation.
From these results, PDGF-BB may regulate oligodendrocyte differentiation from dental pulp stem cells, but not odontoblasts because of the differentiation marker expression after PDGF-BB stimulation. It is important information about the determination of cell fate of dental pulp stem cells and regeneration of neural using dental cells.
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