| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Selenium has been reported its anti-oxidative effects as well as anticancer effects. We investigated the effects of selenium supplementation on x-ray irradiated carcinogenic and non-carcinogenic cells. Sodium selenite (50 nM) supplementation protected non-carcinogenic human esophageal cells against 2Gy X-ray irradiation, while induced cell death to carcinogenic cells.
Oral administration of different chemical forms of selenium to mice for 8 weeks showed metabolism and toxicity differ between selenium compounds. These suggest that selenium supplementation may be useful as adjuvant to enhance efficacy of radiation therapy, but effects and safety of each selenium compound must be evaluated first.
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