| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Hepatocyte growth factor (HGF) exhibits its biological action via up-regulation of prostaglandin (PG) E2 production in many types of cells (HGF-PGE2 axis). So I examined the effect of PGE2 on different types of cells. I clarified that PGE2 inhibits global protein synthesis in lung fibroblasts and macrophages via suppression of protein translation. Moreover, I also found that PGE2 suppresses allergic airway inflammation via inhibition of T cell functions. It is now well accepted that macrophages and T cells play pathogenetic roles in the development of type II diabetes. Moreover, obesity is recognized as an important risk factor for development of asthma and exacerbation of pulmonary fibrosis. My findings described above suggest that HGF-PGE2 axis suppresses not only the development of diabetes in obese individuals but also obese-related pulmonary diseases.
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