Roles of hepatocyte growth factor in obesity and diabetes
| Project/Area Number |
24890035
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | プロスタグランジンE2 / マクロファージ / 肺線維芽細胞 / T細胞 / 翻訳抑制 / 細胞機能抑制 / 喘息 / 糖尿病 / 免疫学 / 細胞・組織 |
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| Research Abstract |
Hepatocyte growth factor (HGF) exhibits its biological action via up-regulation of prostaglandin (PG) E2 production in many types of cells (HGF-PGE2 axis). So I examined the effect of PGE2 on different types of cells. I clarified that PGE2 inhibits global protein synthesis in lung fibroblasts and macrophages via suppression of protein translation. Moreover, I also found that PGE2 suppresses allergic airway inflammation via inhibition of T cell functions. It is now well accepted that macrophages and T cells play pathogenetic roles in the development of type II diabetes. Moreover, obesity is recognized as an important risk factor for development of asthma and exacerbation of pulmonary fibrosis. My findings described above suggest that HGF-PGE2 axis suppresses not only the development of diabetes in obese individuals but also obese-related pulmonary diseases.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Alendronate attenuates eosinophilic airway inflammation associated with suppression of Th2 cytokines, Th17 cytokines, and eotaxin-2.2013
Author(s)
Oh Sasaki, Mitsuru Imamura, Yusuke Yamazumi, Hiroaki Harada, Taku Matsumoto, Katsuhide Okunishi, Kazuyuki Nakagome, Ryoichi Tanaka, Tetsu Akiyama, Kazuhiko Yamamoto and Makoto Dohi
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Journal Title
J. Immunol
Volume: 191
Issue: 6
Pages: 2879-2889
DOI
Related Report
Peer Reviewed
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