Hepatitis B virus evades DNA sensor-mediated IFN signaling pathways through interacting with STING

Research Project

Project/Area Number	24890042
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Gastroenterology
Research Institution	The University of Tokyo
Principal Investigator	TANAKA YASUO 東京大学, 医学部附属病院, 助教 (40422290)
Project Period (FY)	2012-08-31 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	B型肝炎ウイルス / 自然免疫 / DNAセンサー / HBx
Outline of Final Research Achievements	It is not well understood how hepatitis B virus (HBV) evades DNA sensor-mediated IFN signaling pathways. In this study, we have shown that HBV polymerase inhibits STING (stimulator of interferon genes)-mediated IFN signaling pathways. Furthermore, the interaction between HBV polymerase and STING was observed. These results provide an additional molecular mechanism how HBV counteracts the innate immunity and may pave the way for the development of new antiviral therapy.

Report

(3 results)