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Functional analysis of a common variant associated with narcolepsy

Research Project

Project/Area Number 24890047
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionThe University of Tokyo

Principal Investigator

TOYODA Hiromi  東京大学, 医学(系)研究科(研究院), 特任研究員 (90637448)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords睡眠 / 遺伝学 / 免疫 / 精神神経科学
Research Abstract

Narcolepsy is one of hypersomnias. It has been hypothesized that it is caused by autoimmune-mediated loss of orexin-producing neurons, although the detailed mechanism remains unknown. In the present study, we identified a novel narcolepsy-associated gene by genome-wide association study and revealed one possible mechanism how this novel gene contributes to the disease development.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (7 results)

All 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] Genome-wide analysis of CNV (copy number variation) and their associations with narcolepsy in a Japanese population2014

    • Author(s)
      Yamasaki M, Miyagawa T, Toyoda H, Khor SS, Koike A, Nitta A, Akiyama K, Sasaki T, Honda M, and Tokunaga K
    • Journal Title

      J. Hum. Genet.

      Volume: 印刷中 Issue: 5 Pages: 235-240

    • DOI

      10.1038/jhg.2014.13

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.2013

    • Author(s)
      Khor SS, Miyagawa T, Toyoda H, Yamasaki M, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Lin L, Faraco J, Rico T, Honda Y, Honda M, Mignot E, Tokunaga K.
    • Journal Title

      PeerJ

      Volume: 1 Pages: 66-80

    • DOI

      10.7717/peerj.66

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] ゲノムワイド関連解析によるナルコレプシー疾患感受性遺伝子の探索2013

    • Author(s)
      豊田裕美、宮川卓、Khor Seik Soon、川嶋実苗、山崎茉莉亜、小池麻子、田中進、本多裕、本多真、徳永勝士
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      仙台、江陽グランドホテル
    • Year and Date
      2013-11-22
    • Related Report
      2013 Final Research Report
  • [Presentation] ゲノムワイド関連解析によるナルコレプシー疾患感受性遺伝子の探索2012

    • Author(s)
      豊田裕美、宮川卓、Khor Seik Soon、川嶋実苗、山崎茉莉亜、小池麻子、田中進、本多裕、本多真、徳永勝士
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      東京、京王プラザホテル
    • Year and Date
      2012-10-25
    • Related Report
      2013 Final Research Report
  • [Presentation] ゲノムワイド関連解析によるナルコレプシー疾患感受性遺伝子の探索2012

    • Author(s)
      豊田裕美、宮川卓、Khor Seik Soon、川嶋実苗、山崎茉莉亜、小池麻子、田中進、本多裕、本多真、徳永勝士
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      東京、明治大学駿河台キャンパス
    • Year and Date
      2012-09-16
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] ゲノムワイド関連解析によるナルコレプシー疾患感受性遺伝子の探索

    • Author(s)
      豊田裕美、宮川卓、Khor Seik Soon、川嶋実苗、山崎茉莉亜、小池麻子、田中進、本多裕、本多真、徳永勝士
    • Organizer
      日本人類遺伝学会 第58回大会
    • Place of Presentation
      仙台市、江陽グランドホテル
    • Related Report
      2013 Annual Research Report
  • [Presentation] ゲノムワイド関連解析によるナルコレプシー疾患感受性遺伝子の探索

    • Author(s)
      豊田裕美、宮川卓、Khor Seik Soon、川嶋実苗、山崎茉莉亜、小池麻子、田中進、本多裕、本多真、徳永勝士
    • Organizer
      日本人類遺伝学会 第57回大会
    • Place of Presentation
      東京、京王プラザホテル
    • Related Report
      2012 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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