| Project/Area Number |
24890051
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Fundamental nursing
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| Research Institution | Tokyo University of Agriculture (2013)
The University of Tokyo (2012) |
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Principal Investigator |
YAMANE Takumi 東京農業大学, 応用生物科学部, 助教 (80637314)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 創傷 / ドレッシング材 / 創傷被覆材 / moist wound healing |
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| Research Abstract |
Hydrocellular foam dressing has been reported to keep wound exudate at wound surface and promote wound healing; however, the molecular mechanisms responsible for these effects remain unknown. In the present study, we used an animal model to examine the effect of hydrocellular foam dressing (HCF) on wound healing and its regulatory mechanisms related to the concentration and component changes in cytokine and /or growth factor levels in the exudate. Two full-thickness wounds were created in the dorsolateral skin of rats and each wound was covered with either a hydrocellular foam dressing or the film dressing. Wound exudate and periwound skin samples were collected to analyze. We suggested that HCF upregulated the leptin level in the exudate at wound surface, and these effects contribute to wound healing.
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