| Project/Area Number |
24890062
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YASUHIRO Shimizu 東京医科歯科大学, 歯学部附属病院, 医員 (60631968)
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| Co-Investigator(Renkei-kenkyūsha) |
AOKI Kazuhiro 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (40272603)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 咬合異常 / グルココルチコイド |
|---|
| Research Abstract |
Five-week-old C57BL/6J male mice were used in this study. In our murine occlusal disharmony model, a 0.5 mm increase in the vertical height of the occlusion was induced for seven days by the use of a composite resin. The serum corticosterone levels were significantly increased after the induction of occlusal disharmony. Radiological analyses revealed the presence of osteopenia in the lumbar vertebrae and long bones, and a reduction of the mechanical properties in the tibiae and femurs was uncovered by peripheral quantitative computed tomography.
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