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Effects of beta-adrenergic receptor signaling on occlusal disharmony-induced osteoporosis.

Research Project

Project/Area Number 24890062
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

YASUHIRO Shimizu  東京医科歯科大学, 歯学部附属病院, 医員 (60631968)

Co-Investigator(Renkei-kenkyūsha) AOKI Kazuhiro  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (40272603)
Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords咬合異常 / グルココルチコイド
Research Abstract

Five-week-old C57BL/6J male mice were used in this study. In our murine occlusal disharmony model, a 0.5 mm increase in the vertical height of the occlusion was induced for seven days by the use of a composite resin. The serum corticosterone levels were significantly increased after the induction of occlusal disharmony. Radiological analyses revealed the presence of osteopenia in the lumbar vertebrae and long bones, and a reduction of the mechanical properties in the tibiae and femurs was uncovered by peripheral quantitative computed tomography.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (20 results)

All 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (15 results)

  • [Journal Article] Changes of the molar periodontal ligament space and alveolar bone proper induced by occlusal hypofunction in rats2014

    • Author(s)
      Yasuhiro Shimizu, Jun Hosomichi, Saeko Nakamura, Takashi Ono
    • Journal Title

      The Korean Journal of Orthodontics

      Volume: (Accept)(In press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Facilitating mandibular horizontal growth in a Class II high-angle case with a modified functional appliance2014

    • Author(s)
      Yasuhiro Shimizu, Ikuo Yonemitsu, Takashi Ono
    • Journal Title

      Journal of the World Federation of Orthodontists

      Volume: February Issue: 1 Pages: e27-e39

    • DOI

      10.1016/j.ejwf.2014.01.002

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alveolar bone loss induced by the orthodontic tooth movement under hypofunctional conditions in rats.2013

    • Author(s)
      Chisa Shitano, Otto Baba, Sawa Kaneko, Jun Hosomichi, Yasuhiro Shimizu, Naoki Shibutani,; Risa Usumi-Fujita, Yoshiro Takano, Takashi Ono
    • Journal Title

      Orthodontic Waves

      Volume: 72 Issue: 4 Pages: 148-155

    • DOI

      10.1016/j.odw.2013.07.002

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Soft diet causes greater alveolar osteopenia in the mandible than in the maxilla.2013

    • Author(s)
      Yasuhiro Shimizu, Takayoshi Ishida, Jun Hosomichi, Sawa Kaneko, Kasumi Hatano, and Takashi Ono
    • Journal Title

      Archives of Oral Biology

      Volume: 未 Issue: 8 Pages: 907-11

    • DOI

      10.1016/j.archoralbio.2013.02.003

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occlusal hypofunction causes periodontal atrophy and VEGF/VEGFR inhibition in tooth movement.2013

    • Author(s)
      Usumi-Fujita R, Hosomichi J, Ono N, Shibutani N, Kaneko S, Shimizu Y, Ono T.
    • Journal Title

      Angle Orthodontist

      Volume: 83(1) Issue: 1 Pages: 48-56

    • DOI

      10.2319/011712-45.1

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] The effects of the RANK-like peptide on murine rheumatoid arthritis model2014

    • Author(s)
      Genki Kato, Yasuhiro Shimizu, Yasutaka Sugamori, Mariko Takahashi, Yukihiko Tamura, Takashi Ono, Keiichi Ohya, Kazuhiro Aoki
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] The effects of the RANK-like peptide on murine rheumatoid arthritis model.2014

    • Author(s)
      Genki Kato, Yasuhiro Shimizu, Yasutaka Sugamori, Mariko Takahashi, Yukihiko Tamura, Takashi Ono, Keiichi Ohya, Kazuhiro Aoki.
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台(宮城県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 咬合異常によるストレスホルモンの上昇が骨密度に与える影響~マウス成長期咬合異常モデルを用いた長管骨骨密度解析~2013

    • Author(s)
      清水康広、青木和広、カーン・マスード、細道純、金香佐和、大谷啓一、小野卓史
    • Organizer
      第11回日本歯科骨粗鬆症研究会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-02
    • Related Report
      2013 Final Research Report
  • [Presentation] An Osteoprotegerin-like Peptide Prevents Bone Loss in Collagen-Induced Murine Arthritis2013

    • Author(s)
      Genki Kato, Yasuhiro Shimizu, Md Abdullah Al Mamun, Ramachandran Murali, Keiichi Ohya, Kazuhiro Aoki
    • Organizer
      The 3rd Tri-University Consortium on Oral Science and Education
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] 成長期における間欠的低酸素がラット顎顔面領域の骨成長に及ぼす影響について2013

    • Author(s)
      大石修史,清水康広,細道純,隈陽一郎,前田秀将,臼見莉沙,金香佐和,舌野知佐,吉田謙一,小野卓史
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      松本
    • Related Report
      2013 Final Research Report
  • [Presentation] 成長期における間欠的低酸素がラット鼻腔気道の三次元形態に与える影響2013

    • Author(s)
      隈陽一郎、臼見莉沙、細道純、大石修史、永井恒志、清水康広、金香佐和、舌野知佐、鈴木淳一、吉田謙一、小野卓史
    • Organizer
      第72回日本矯正歯科学会学術大会
    • Place of Presentation
      松本
    • Related Report
      2013 Final Research Report
  • [Presentation] Alveolar bone loss induced by hypofunctional tooth movement in rats2013

    • Author(s)
      C. SHITANO, O. BABA, S. KANEKO, J. HOSOMICHI, Y. SHIMIZU, N. SHIBUTANI, R. USUMI-FUJITA, Y. T AKANO, T. ONO
    • Organizer
      IADR APR Regional Meeting and Co-Annual Scientific Meeting of IADR Divisions
    • Place of Presentation
      Bangkok
    • Related Report
      2013 Final Research Report
  • [Presentation] An Osteoprotegerin-like Peptide Prevents Bone Loss in Collagen-Induced Murine Arthritis.2013

    • Author(s)
      Genki Kato, Yasuhiro Shimizu, Md Abdullah Al Mamun, Ramachandran Murali, Keiichi Ohya, Kazuhiro Aoki.
    • Organizer
      Tri-University Consortium on Oral Science and Education.
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Annual Research Report
  • [Presentation] Alveolar bone loss induced by hypofunctional tooth movement in rats2013

    • Author(s)
      C. SHITANO, O. BABA, S. KANEKO, J. HOSOMICHI, Y. SHIMIZU, N. SHIBUTANI, R. USUMI-FUJITA, Y. T AKANO, T. ONO.
    • Organizer
      IADR APR Regional Meeting and Co-Annual Scientific Meeting of IADR Divisions
    • Place of Presentation
      Bangkok (Thailand)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 成長期における間欠的低酸素がラット鼻腔気道の三次元形態に与える影響2013

    • Author(s)
      隈陽一郎、臼見莉沙、細道純、大石修史、永井恒志、清水康広、金香佐和、舌野知佐、鈴木淳一、吉田謙一、小野卓史.
    • Organizer
      第72回日本矯正歯科学会学術大会
    • Place of Presentation
      松本(長野県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 成長期における間欠的低酸素がラット顎顔面領域の骨成長に及ぼす影響について2013

    • Author(s)
      大石修史,清水康広,細道純,隈陽一郎,前田秀将,臼見莉沙,金香佐和,舌野知佐,吉田謙一,小野卓史
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      松本(長野県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 咬合異常によるストレスホルモンの上昇が骨密度に与える影響 ~マウス成長期咬合異常モデルを用いた長管骨骨密度解析~2013

    • Author(s)
      清水康広、青木和広、カーン・マスード、細道純、金香佐和、大谷啓一、小野卓史
    • Organizer
      第11回日本歯科骨粗鬆症研究会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 軟性飼料飼育した成長期ラットの歯槽骨は上下顎骨において異なる構造変化を示す2012

    • Author(s)
      清水康広、石田宝義、細道純、金香佐和、小野卓史
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] 咬合刺激低下歯の矯正学的移動に伴う歯槽骨の変化について2012

    • Author(s)
      舌野知佐、馬場麻人、金香佐和、細道純、渋谷直樹、清水康広、臼見莉沙、高野吉郎、小野卓史
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] 矯正患者の顎関節症状に関するアンケート調査2012

    • Author(s)
      加藤千帆、臼見莉沙、呉育子、清水康広、小池紗里奈、古森佐知子、柴田真衣、石田宝義、渡一平、簡野瑞誠、小野卓史
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Final Research Report 2012 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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