Analysis of miRNA in the liver cancer stem cell: For cancer chemoprevention and metastasis suppression

• Project/Area Number: 24890081
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Gifu University
• Principal Investigator: SUETSUGU Atushi 岐阜大学, 医学部附属病院, 助教 (30340079)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 肝癌 / 癌幹細胞 / miRNA

Research Abstract

Cancer cells form microenvironment in primary tumor and metastatic formation. The cancer-associated cells play an important role. Cancer-associated fibroblast cells and tumor-associated macrophages are important at the time of the liver metastasis formation. Cancer cells shed exosomes and transfer exosomal molecules to fibroblast cells during tumor progression. We confirmed that cancer cells release exosomes into the circulation of mice with liver metastasis. We collected blood from mice and detected exosomes. Imaging of exosomes can contribute to understanding the role of intercellular communication in tumor progression. Tumor-drived exosomes have been viewd as a mediater to condition tissues and prepare niches for metastasis.

Research Products

• [Journal Article] Pharmaceutical and nutraceutical approaches for preventing liver carcinogenesis : chemoprevention of hepatocellular carcinoma using acyclic retinoid and branched-chain amino acids (2014)
  • Author(s): Shimizu M, Shirakami Y, Hanai T, Imai K, Suetsugu A, Takai K, Shiraki M, Moriwaki H
  • Journal Title: Mol Nutr Food Res. Volume: 58(1) Pages: 124-35
• [Journal Article] Free fatty acid as a marker of energy malnutrition in liver cirrhosis (2014)
  • Author(s): Hanai T, Shiraki M, Nishimura K, Imai K, Suetsugu A, Takai K, Shimizu M, Naiki T, Moriwaki H
  • Journal Title: Hepatol Res. Volume: 44(2) Pages: 218-28
• [Journal Article] Pharmaceutical and nutraceutical approaches for preventing liver carcinogenesis: chemoprevention of hepatocellular carcinoma using acyclic retinoid and branched-chain amino acids. (2014)
  • Author(s): Shimizu M, Shirakami Y, Hanai T, Imai K, Suetsugu A, Takai K, Shiraki M, Moriwaki H.
  • Journal Title: Mol Nutr Food Res. Volume: 58 Issue: 1 Pages: 124-135
  • DOI: 10.1002/mnfr.201300538
  • Peer Reviewed
• [Journal Article] Efficacy of Salmonella typhimurium A1-R Versus Chemotherapy on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX). (2014)
  • Author(s): Hiroshima Y, Zhao M, Maawy A, Zhang Y, Katz MH, Fleming JB, Uehara F, Miwa S, Yano S, Momiyama M, Suetsugu A, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
  • Journal Title: J Cell Biochem Volume: 115(7) Issue: 7 Pages: 1254-61
  • DOI: 10.1002/jcb.24769
  • Peer Reviewed
• [Journal Article] Imaging the efficacy of UVC irradiation on superficial brain tumors and metastasis in live mice at the subcellular level (2013)
  • Author(s): Momiyama M, Suetsugu A, Kimura H, Kishimoto H, Aki R, Yamada A, Sakurada H, Chishima T, Bouvet M, Endo I, Hoffman RM
  • Journal Title: J Cell Biochem. Volume: 114(2) Pages: 428-34
• [Journal Article] Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude mouse models (2013)
  • Author(s): Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman RM
  • Journal Title: Adv Drug Deliv Rev. Volume: 65(3) Pages: 383-90
• [Journal Article] Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice (2013)
  • Author(s): Momiyama M, Suetsugu A, Chishima T, Bouvet M, Endo I, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 33(1) Pages: 103-6
• [Journal Article] Enhanced resection of orthotopic red-fluorescent-protein-expressing human glioma by fluorescence-guided surgery in nude mice (2013)
  • Author(s): Momiyama M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Yano S, Bouvet M, Chishima T, Endo I, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 33(1) Pages: 107-11
• [Journal Article] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer (2013)
  • Author(s): Osawa Y, Suetsugu A, Matsushima-Nishiwaki R, Yasuda I, Saibara T, Moriwaki H, Seishima M, Kozawa O
  • Journal Title: J Clin Invest. Volume: 123(2) Pages: 834-43
• [Journal Article] Dynamic subcellular imaging of cancer cell mitosis in the brain of live mice (2013)
  • Author(s): Momiyama M, Suetsugu A, Kimura H, Chishima T, Bouvet M, Endo I, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 33(4) Pages: 1367-71
• [Journal Article] In vivo fluorescence imaging reveals the promotion of mammary tumorigenesis by mesenchymal stromal cells (2013)
  • Author(s): Ke CC, Liu RS, Suetsugu A, Kimura H, Ho JH, Lee OK, Hoffman RM
  • Journal Title: PLoS One Volume: 8(7)
• [Journal Article] Comparison of efficacy of Salmonella typhimurium A1-R and chemotherapy on stem-like and non-stem human pancreatic cancer cells (2013)
  • Author(s): Hiroshima Y, Zhao M, Zhang Y, Maawy A, Hassanein MK, Uehara F, Miwa S, Yano S, Momiyama M, Suetsugu A, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM
  • Journal Title: Cell Cycle Volume: 12(17) Pages: 2774-80
• [Journal Article] Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling (2013)
  • Author(s): He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M
  • Journal Title: Cell Volume: 155(2) Pages: 384-96
• [Journal Article] Imaging nuclear - cytoplasm dynamics of cancer cells in the intravascular niche of live mice (2013)
  • Author(s): Suetsugu A, Jiang P, Moriwaki H, Saji S, Bouvet M, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 33(10) Pages: 4229-36
• [Journal Article] Development of a clinically-precise mouse model of rectal cancer (2013)
  • Author(s): Kishimoto H, Momiyama M, Aki R, Kimura H, Suetsugu A, Bouvet M, Fujiwara T, Hoffman RM
  • Journal Title: PLoS One Volume: 8(11)
• [Journal Article] Imaging the efficacy of UVC irradiation on superficial brain tumors and metastasis in live mice at the subcellular level. (2013)
  • Author(s): Momiyama M, Suetsugu A, Kimura H, Kishimoto H, Aki R, Yamada A, Sakurada H, Chishima T, Bouvet M, Endo I, Hoffman RM.
  • Journal Title: J Cell Biochem Volume: 114 (2) Issue: 2 Pages: 428-34
  • DOI: 10.1002/jcb.24381
  • Peer Reviewed
• [Journal Article] Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude mouse models. (2013)
  • Author(s): Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman RM.
  • Journal Title: Adv Drug Deliv Rev. Volume: 65 Issue: 3 Pages: 383-390
  • DOI: 10.1016/j.addr.2012.08.007
  • Peer Reviewed
• [Journal Article] Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice. (2013)
  • Author(s): Momiyama M, Suetsugu A, Chishima T, Bouvet M, Endo I, Hoffman RM.
  • Journal Title: Anticancer Res. Volume: 33 Pages: 103-106
  • Peer Reviewed
• [Journal Article] Enhanced resection of orthotopic red-fluorescent-protein-expressing human glioma by fluorescence-guided surgery in nude mice. (2013)
  • Author(s): Momiyama M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Yano S, Bouvet M, Chishima T, Endo I, Hoffman RM.
  • Journal Title: Anticancer Res. Volume: 33 Pages: 107-111
  • Peer Reviewed
• [Journal Article] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer． (2013)
  • Author(s): Osawa Y,Saibara T et.al
  • Journal Title: Journal Clin Invest Volume: 123(2) Pages: 834-843
  • DOI: 10.1172/jci65188
  • Peer Reviewed
• [Journal Article] Dynamic subcellular imaging of cancer cell mitosis in the brain of live mice. (2013)
  • Author(s): Momiyama M, Suetsugu A, Kimura H, Chishima T, Bouvet M, Endo I, Hoffman RM.
  • Journal Title: Anticancer Res. Volume: 33 Pages: 1367-1371
  • Peer Reviewed
• [Journal Article] Free fatty acid as a marker of energy malnutrition in liver cirrhosis. (2013)
  • Author(s): Hanai T, Shiraki M, Nishimura K, Imai K, Suetsugu A, Takai K, Shimizu M, Naiki T, Moriwaki H.
  • Journal Title: Hepatol Res. Volume: 44 Issue: 2 Pages: 218-228
  • DOI: 10.1111/hepr.12112
  • Peer Reviewed
• [Journal Article] In vivo fluorescence imaging reveals the promotion of mammary tumorigenesis by mesenchymal stromal cells. (2013)
  • Author(s): Ke CC, Liu RS, Suetsugu A, Kimura H, Ho JH, Lee OK, Hoffman RM.
  • Journal Title: PLoS One. Volume: 8 Issue: 7 Pages: e69658-e69658
  • DOI: 10.1371/journal.pone.0069658
  • Peer Reviewed
• [Journal Article] Comparison of efficacy of Salmonella typhimurium A1-R and chemotherapy on stem-like and non-stem human pancreatic cancer cells. (2013)
  • Author(s): Hiroshima Y, Zhao M, Zhang Y, Maawy A, Hassanein MK, Uehara F, Miwa S, Yano S, Momiyama M, Suetsugu A, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
  • Journal Title: Cell Cycle Volume: 1;12(17) Issue: 17 Pages: 2774-80
  • DOI: 10.4161/cc.25872
  • Peer Reviewed
• [Journal Article] Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. (2013)
  • Author(s): He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M.
  • Journal Title: Cell. Volume: 155 Issue: 2 Pages: 384-396
  • DOI: 10.1016/j.cell.2013.09.031
  • Peer Reviewed
• [Journal Article] Imaging nuclear - cytoplasm dynamics of cancer cells in the intravascular niche of live mice. (2013)
  • Author(s): Suetsugu A, Jiang P, Moriwaki H, Saji S, Bouvet M, Hoffman RM.
  • Journal Title: Anticancer Res. Volume: 33 Pages: 4229-4236
  • Peer Reviewed
• [Journal Article] Development of a clinically-precise mouse model of rectal cancer. (2013)
  • Author(s): Kishimoto H, Momiyama M, Aki R, Kimura H, Suetsugu A, Bouvet M, Fujiwara T, Hoffman RM
  • Journal Title: PLoS One Volume: 8 Issue: 11 Pages: e79453-e79453
  • DOI: 10.1371/journal.pone.0079453
  • Peer Reviewed
• [Journal Article] Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice. (2013)
  • Author(s): 13. Momiyama M
  • Journal Title: Anticancer Res Volume: 33 Pages: 103-106
  • Peer Reviewed
• [Journal Article] Enhanced resection of orthotopic red-fluorescent-protein-expressing human glioma by fluorescence-guided surgery in nude mice. (2013)
  • Author(s): 15. Momiyama M
  • Journal Title: Anticancer Res Volume: 33 Pages: 107-111
  • Peer Reviewed
• [Journal Article] Efficacy against lung metastasis with a tumor-targeting mutant of Salmonella typhimurium in immunocompetent mice (2012)
  • Author(s): Zhao M, Suetsugu A, Ma H, Zhang L, Liu F, Zhang Y, Tran B, Hoffman RM
  • Journal Title: Cell Cycle Volume: 1 Pages: 187-93
• [Journal Article] The cyan fluorescent protein nude mouse as a host for multicolor-coded imaging models of primary and metastatic tumor microenvironments (2012)
  • Author(s): Suetsugu A, Hassanein MK, Reynoso J, Osawa Y, Nagaki M, Moriwaki H, Saji S, Bouvet M, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 1 Pages: 31-8
• [Journal Article] Imageable Metastasis Occuring in Transgenic GFP Mice Orthotopically Implanted with Human-Patient Primary Pancreatic Cancer Specimens (2012)
  • Author(s): Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Saji S, Moriwaki H, Bouvet M, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 4 Pages: 1175-80
• [Journal Article] Major liver resection stimulates atromal recruitment and metastasis compared with repeated minor resection (2012)
  • Author(s): Momiyama M, Kumamoto T, Suetsugu A, Kishimoto H, Chishima T, Tanaka K, Akiyama H, Ichikawa Y, Bouvet M, Endo I, Hoffman RM
  • Journal Title: J Surg Res. Volume: 178(1) Pages: 280-7
• [Journal Article] Multi-color pallet of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens (2012)
  • Author(s): Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Moriwaki H, Bouvet M, Saji S, Hoffman RM
  • Journal Title: J Cell Biochem. Volume: 7 Pages: 2290-5
• [Journal Article] Inhibition of metastasis of circulating human prostate cancer cells in the chick embryo by an extracellular matrix produced by foreskin fibroblasts in culture (2012)
  • Author(s): Menen R, Pinney E, Hassanein MK, Kolostova K, Bobek V, Suetsugu A, Zhang N, Bouvet M, Naughton GK, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 5 Pages: 1573-7
• [Journal Article] Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice (2012)
  • Author(s): Zhang Y, Tome Y, Suetsugu A, Zhang L, Zhang N, Hoffman RM, Zhao M
  • Journal Title: Anticancer Res. Volume: 7 Pages: 2501-8
• [Journal Article] Real-time imaging of apoptosis induction of human breast cancer cells by the traditional Chinese medicinal herb tubeimu (2012)
  • Author(s): Hu M, Zhao M, An C, Yang M, Li Q, Zhang Y, Suetsugu A, Tome Y, Yano S, Fu Y, Hoffman RM, Hu K
  • Journal Title: Anticancer Res. Volume: 7 Pages: 2509-14
• [Journal Article] Tumor-educated macrophages promote tumor growth and peritoneal metastasis in an orthotopic nude mouse model of human pancreatic cancer (2012)
  • Author(s): Menen RS, Hassanein MK, Momiyama M, Suetsugu A, Moossa AR, Hoffman RM, Bouvet M
  • Journal Title: In Vivo. Volume: 26(4) Pages: 565-9
• [Journal Article] Non-invasive Fluorescent-protein Imaging of Orthotopic Pancreatic-cancer-patient Tumorgraft Progression in Nude Mice (2012)
  • Author(s): Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Saji S, Moriwaki H, Bouvet M, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 8 Pages: 3063-7
• [Journal Article] Fluorescent proteins enhance UVC PDT of cancer cells (2012)
  • Author(s): Momiyama M, Suetsugu A, Kimura H, Kishimoto H, Aki R, Yamada A, Sakurada H, Chishima T, Bouvet M, Bulgakova NN, Endo I, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 10
• [Journal Article] Efficacy against lung metastasis with a tumor-targeting mutant of Salmonella typhimurium in immunocompetent mice. (2012)
  • Author(s): Zhao M
  • Journal Title: Cell Cycle Volume: 1 Issue: 1 Pages: 187-193
  • DOI: 10.4161/cc.11.1.18667
  • Peer Reviewed
• [Journal Article] The cyan fluorescent protein nude mouse as a host for multicolor-coded imaging models of primary and metastatic tumor microenvironments. (2012)
  • Author(s): Suetsugu A
  • Journal Title: Anticancer Res Volume: 1 Pages: 31-38
  • Peer Reviewed
• [Journal Article] Imageable Metastasis Occuring in Transgenic GFP Mice Orthotopically Implanted with Human-Patient Primary Pancreatic Cancer Specimens. (2012)
  • Author(s): Suetsugu A
  • Journal Title: Anticancer Res Volume: 4 Pages: 1175-1180
  • Peer Reviewed
• [Journal Article] Major liver resection stimulates atromal recruitment and metastasis compared with repeated minor resection. (2012)
  • Author(s): Momiyama M
  • Journal Title: J Surg Res Volume: 178 Issue: 1 Pages: 280-287
  • DOI: 10.1016/j.jss.2012.03.020
  • Peer Reviewed
• [Journal Article] Multi-color pallet of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens. (2012)
  • Author(s): Suetsugu A
  • Journal Title: J Cell Biochem Volume: 7 Issue: 7 Pages: 2290-2295
  • DOI: 10.1002/jcb.24099
  • Peer Reviewed
• [Journal Article] Inhibition of metastasis of circulating human prostate cancer cells in the chick embryo by an extracellular matrix produced by foreskin fibroblasts in culture. (2012)
  • Author(s): Menen R
  • Journal Title: Anticancer Res Volume: 5 Pages: 1573-1577
  • Peer Reviewed
• [Journal Article] Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice. (2012)
  • Author(s): Zhang Y
  • Journal Title: Anticancer Res Volume: 7 Pages: 2501-2508
  • Peer Reviewed
• [Journal Article] Real-time imaging of apoptosis induction of human breast cancer cells by the traditional Chinese medicinal herb tubeimu. (2012)
  • Author(s): Hu M
  • Journal Title: Anticancer Res Volume: 7 Pages: 2509-2514
  • Peer Reviewed
• [Journal Article] Tumor-educated macrophages promote tumor growth and peritoneal metastasis in an orthotopic nude mouse model of human pancreatic cancer. (2012)
  • Author(s): Menen RS
  • Journal Title: In Vivo Volume: 26 Pages: 565-569
  • Peer Reviewed
• [Journal Article] Non-invasive Fluorescent-protein Imaging of Orthotopic Pancreatic-cancer-patient Tumorgraft Progression in Nude Mice. (2012)
  • Author(s): Suetsugu A
  • Journal Title: Anticancer Res Volume: 8 Pages: 3063-3067
  • Peer Reviewed
• [Journal Article] Fluorescent proteins enhance UVC PDT of cancer cells. (2012)
  • Author(s): Momiyama M
  • Journal Title: Anticancer Res Volume: 10 Pages: 4327-4330
  • Peer Reviewed
• [Presentation] HIV感染治療開始後に伴うB型肝炎の免疫再構築症候群の検討末次淳 (2013)
  • Author(s): 宮崎恒起、華井竜徳、今井健二、白木亮、高井光治、清水雅仁、内木隆文、鶴見寿、森脇久隆
  • Organizer: JDDW
  • Place of Presentation: 東京
  • Year and Date: 2013-10-10
• [Presentation] 当院におけるC型慢性肝炎に対する3剤併用療法の初期治療効果と副作用の検討末次淳 (2013)
  • Author(s): 宮崎恒起、華井竜徳、今井健二、白木亮、高井光治、大澤陽介、清水雅仁、内木隆文、森脇久隆
  • Organizer: JDDW
  • Place of Presentation: 東京
  • Year and Date: 2013-10-09
• [Presentation] Comparison of Salmonella typhimurium A1-R and chemotherapy of human-patient pancreatic tumorgrafts (2013)
  • Author(s): Hiroshima Y, Zhao M, Zhang Y, Ali Maawy, Hassanein MK, Suetsugu A, Chishima T, Kuniya Tanaka, Micheal Bouvet, Endo I, Hoffman RM
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2013-10-05
• [Presentation] Cell cycle position and chemoresponse depends on location in tumor (2013)
  • Author(s): Tome Y, Michelle A. Digman, Momiyama M, Suetsugu A, Enrico Gratton, Yano S, Hoffman RM
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2013-10-03
• [Presentation] C型慢性肝炎IFN治療SVR後の発癌症例の検討末次淳 (2013)
  • Author(s): 内木隆文、森脇久隆
  • Organizer: 第40回日本肝臓学会西部会 シンポジウム
• [Presentation] Salmonella typhimurium A1-R targets chemoresistant stem-like human pancreatic cancer cells (2013)
  • Author(s): Hiroshima Y, Zhao M, Zhang Y, Ali Maawy, Hassanein MK, Suetsugu A, Chishima T, Kuniya Tanaka, Bouvet M, Endo I, Hoffman RM
  • Organizer: American Society of Clinical Oncology (ASCO)
  • Place of Presentation: Chicago, Illinois
• [Presentation] Salmonella typhimurium A1-R effectively targets human-patient pancreatic tumorgrafts in nude mice (2013)
  • Author(s): Zhao M, Katz MH, Fleming J, Suetsugu A, Zhang Y, Ali Maawy, Chishima T, Kuniya Tanaka, Bouvet M, Endo I, Hoffman RM, Hiroshima Y
  • Organizer: American Society of Clinical Oncology (ASCO)
  • Place of Presentation: Chicago, Illinois
• [Presentation] CHARACTERIZATION AND IMAGING OF CD133+ LIVER CANCER STEM CELLS (2013)
  • Author(s): Suetsugu A, Y. Osawa, H. Aoki, T. Kunisada, H. Tsurumi,R.M. Hoffman, H. Moriwaki
  • Organizer: European Association for the Study of the Liver (EASL)
  • Place of Presentation: Amsterdam (The Netherlands)
• [Presentation] ACID SPHINGOMYELINASE INHIBITS GROWTH OF METASTATIC LIVER TUMOR (2013)
  • Author(s): Y. Osawa, A. Suetsugu, H. Moriwaki, O. Kozawa
  • Organizer: European Association for the Study of the Liver (EASL)
  • Place of Presentation: Amsterdam (The Netherlands)
• [Presentation] Efficacy of Salmonella typhimurium A1-R on chemoresistant stem-like human pancreatic cancer cells (2013)
  • Author(s): Hiroshima Y, Zhao M, Zhang Y, Ali Maawy, Mohamed Hassanein, Suetsugu A, Chishima T, Kuniya Tanaka, Bouvet M, Endo I, Hoffman RM
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC
• [Presentation] Cancer cell location in tumor determines cell cycle position and dormancy (2013)
  • Author(s): Yano S, Tome Y, Michelle Digman, Momiyama M, Suetsugu A, Enrico Gratton, Hoffman RM
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC
• [Presentation] Imaging of methioninase-induced S/G_2-phase-trapping for subsequent effective chemotherapy (2013)
  • Author(s): Yano S, Tome Y, Michelle Digman, Momiyama M, Suetsugu A, Enrico Gratton, Hoffman RM
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC
• [Presentation] Efficacy of Salmonella typhimurium A1-R treatment on human patient pancreatic tumorgrafts (2013)
  • Author(s): Zhao M, Katz MH, Fleming J, Suetsugu A, Zhang Y, Ali Maawy, Chishima T, Kuniya Tanaka, Bouvet M, Hiroshima Y, Endo I, Hoffman RM
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC
• [Presentation] Imaging exosome transfer from colon cancer cells to stroma at liver metastatic sites in nude mouse (2013)
  • Author(s): Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman RM. Hoffman RM
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC
• [Presentation] Efficacy of Salmonella typhimurium A1-R on chemoresistant stem-like human pancreatic cancer cells (2013)
  • Author(s): Yukihiko Hiroshima, Ming Zhao, Yong Zhang, Ali Maawy, Mohamed Hassanein, Atsushi Suetsugu, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman.
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC, （アメリカ）
• [Presentation] Cancer cell location in tumor determines cell cycle position and dormancy (2013)
  • Author(s): Shuya Yano, Yasunori Tome, Michelle Digman, Masashi Momiyama, Atsushi Suetsugu, Enrico Gratton, Robert M. Hoffman.
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC, （アメリカ）
• [Presentation] Imaging of methioninase-induced S/G2-phase-trapping for subsequent effective chemotherapy (2013)
  • Author(s): Shuya Yano, Yasunori Tome, Michelle Digman, Masashi Momiyama, Atsushi Suetsugu, Enrico Gratton, Robert M. Hoffman.
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC, （アメリカ）
• [Presentation] Efficacy of Salmonella typhimurium A1-R treatment on human patient pancreatic tumorgrafts (2013)
  • Author(s): Ming Zhao, Matthew H.G. Katz, Jason B. Fleming, Atsushi Suetsugu, Yong Zhang, Ali Maawy, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Yukihiko Hiroshima, Itaru Endo, Robert M. Hoffman.
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC, （アメリカ）
• [Presentation] Imaging exosome transfer from colon cancer cells to stroma at liver metastatic sites in nude mouse (2013)
  • Author(s): Atsushi Suetsugu, Kimi Homma, Shigetoyo Saji, Hisataka Moriwaki, Takahiro Ochiya, Robert M. Hoffman.
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC, （アメリカ）
• [Presentation] CHARACTERIZATION AND IMAGING OF CD133+ LIVER CANCER STEM CELLS (2013)
  • Author(s): A. Suetsugu, Y. Osawa, H. Aoki, T. Kunisada, H. Tsurumi,R.M. Hoffman, H. Moriwaki
  • Organizer: European Association for the Study of the Liver (EASL)
  • Place of Presentation: Amsterdam, （オランダ）
• [Presentation] ACID SPHINGOMYELINASE INHIBITS GROWTH OF METASTATIC LIVER TUMOR (2013)
  • Author(s): Y. Osawa, A. Suetsugu, H. Moriwaki, O. Kozawa
  • Organizer: European Association for the Study of the Liver (EASL)
  • Place of Presentation: Amsterdam, （オランダ）
• [Presentation] Salmonella typhimurium A1-R targets chemoresistant stem-like human pancreatic cancer cells. (2013)
  • Author(s): Yukihiko Hiroshima, Ming Zhao, Yong Zhang, Ali Maawy, Mohamed K. Hassanein, Atsushi Suetsugu, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
  • Organizer: American Society of Clinical Oncology (ASCO)
  • Place of Presentation: Chicago, （アメリカ）
• [Presentation] Salmonella typhimurium A1-R effectively targets human-patient pancreatic tumorgrafts in nude mice. (2013)
  • Author(s): Ming Zhao, Matthew H. G. Katz, Jason B. Fleming, Atsushi Suetsugu, Yong Zhang, Ali Maawy, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman, Yukihiko Hiroshima
  • Organizer: American Society of Clinical Oncology (ASCO)
  • Place of Presentation: Chicago, （アメリカ）
• [Presentation] シンポジウム C型慢性肝炎IFN治療SVR後の発癌症例の検討 (2013)
  • Author(s): 末次 淳、内木隆文、森脇久隆
  • Organizer: 第40回日本肝臓学会西部会
  • Place of Presentation: 岐阜
• [Presentation] Highly-effective resection of orthotopic human glioma by fluorescence-guided surgry in nude mice (2012)
  • Author(s): Momiyama M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Syuya Yano, Micheal Bouvet, Chishima T, Endo I, Hoffman RM
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] Treatment of brain tumors in nude mice with intra-cranial UV irradiation (2012)
  • Author(s): Satoshi Hasegawa, Momiyama M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Syuya Yano, Chishima T, Micheal Bouvet, Hoffman RM
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] Role of stellate cells during liver metastasis of pancreatic cancer in nude mice Cynthia Snyder (2012)
  • Author(s): Suetsugu A, Moriwaki H, Saji S, Micheal Bouvet, Hoffman RM
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-20
• [Presentation] Paxillin-expressing breast cancer imaged by raster-image-correlation spectroscopy of GFP in vivo and in vitro (2012)
  • Author(s): Suetsugu A, Michelle Digman, Federica Sabatini, Moriwaki H, Saji S, Micheal Bouvet, Enrico Grattion, Hoffman RM
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-19
• [Presentation] Use of fluorescent protein labeling of storoma to image orthotopic pancreatic patient tumors in nude mice (2012)
  • Author(s): Hoffman RM, Suetsugu A, Matthew H Katz, Fleming J, Mark Truty, Ryan Thomas, Hassanein MK, Moriwaki H, Micheal Bouvet, Saji S
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-19
• [Presentation] Trafficking of exosomes imaged in vivo with GFP (2012)
  • Author(s): Ochiya T, Kimi Honma, Suetsugu A
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-19
• [Presentation] Making patient tumors glow in nude mice by coloring the stroma with fluorescent proteins (2012)
  • Author(s): Suetsugu A, Katz MH, Fleming J, Mark Truty, Saji S, Moriwaki H, Bouvet M, Hoffman RM
  • Organizer: 第10回日本臨床腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2012-07-27
• [Presentation] RFP-expressing glioma successfully resected in othotopic mouse models using fluorescence-guided surgery (2012)
  • Author(s): Momiyama M, Suetsugu A, Kishimoto H, Chishima T, Bouvet M, Endo I
  • Organizer: World Molecular imaging congress (WMIC) 2012
  • Place of Presentation: Dublin
• [Presentation] Multi-color imaging model of the tumor environment (2012)
  • Author(s): Suetsugu A, Katz MH, Fleming J, Hassanein MK, Moriwaki H, Bouvet M, Saji S, Hoffman RM
  • Organizer: 第21回日本がん転移学会学術集会・総会
  • Place of Presentation: 金沢
• [Presentation] Salmonella typhimurim can eradicate human glioma in a nude mouse orthotopic model (2012)
  • Author(s): Momiyama M, Zhao M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Syuya Yano, Micheal Bouvet, Chishima T, Endo I, Hoffman RM
  • Organizer: 第21回日本がん転移学会学術集会・総会
  • Place of Presentation: 金沢
• [Presentation] Effect of major liver resection on colon cancer metastasis in the lung and liver (2012)
  • Author(s): Hoffman RM, Momiyama M, Suetsugu A, Kishimoto H, Chishima T, Bouvet M, Endo I
  • Organizer: American Society of Clinical Oncology (ASCO) 2012
  • Place of Presentation: Chicago
• [Presentation] Determining the metastatic potential of circulating tumor cells (2012)
  • Author(s): Menen RS, Emmett Pinney, Katarina Kolostova, Vladimir Bobek, Suetsugu A, Nan Zhang, Hoffman RM
  • Organizer: American Society of Clinical Oncology (ASCO) 2012
  • Place of Presentation: Chicago
• [Presentation] L-tryptophan-mediated enhancement of susceptibility to NAFLD is dependent on the mTOR (2012)
  • Author(s): Yosuke Osawa, Yoichi Yasuda, Suetsugu A, Moriwaki H, Osamu Kozawa
  • Organizer: Asian pacific Digestive Week 2012
  • Place of Presentation: Bangkok,Thailand
• [Presentation] Potential use of CD133-positive bone marrow cells in the treatment of liver fibrosis (2012)
  • Author(s): Suetsugu A, Yosuke Osawa, Hitomi Aoki, Takahiro Kunisada, Ogata H, Hisashi Tsurumi, Hoffman RM, Moriwaki H
  • Organizer: Asian pacific Digestive Week 2012
  • Place of Presentation: Bangkok,Thailand
• [Presentation] Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice (2012)
  • Author(s): Zhang Y, Suetsugu A, Nan Zhang, Lei Zhang, Hoffman RM, Zhao M
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
• [Presentation] In vivo tracking of cancer-cell-derived exosomes (2012)
  • Author(s): Honma K, Suetsugu A, Ochiya T, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
• [Presentation] Multicolor imageable orthotopic tumorgraft models of human patient pancreatic cancer (2012)
  • Author(s): Suetsugu A, Katz MH, Fleming J, Hassanein MK, Moriwaki H, Bouvet M, Saji S, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
• [Presentation] Imaging stromal recruitment during liver metastasis formation in the GFP-MUP-uPA mouse (2012)
  • Author(s): Suetsugu A, Ogata H, Moriwaki H, Saji S, Karin M, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
• [Presentation] Tumor-educated macrophages promote tumor growth and peritoneal metastasis in an orthotopic nude mouse model of human pancreatic cancer (2012)
  • Author(s): Menen RS, Hassanein MK, Momiyama M, Suetsugu A, Abdool R. Moossa, Bouvet M, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
• [Presentation] Imaging sub-cellular dynamics of proliferating intra- and extra-vascular cancer cells (2012)
  • Author(s): Suetsugu A, Michelle Digman, Jose A. Aguilar, Ping Jiang, Mohamed Hassanein, Moriwaki H, Bouvet M, Saji S, Enrico Gratton, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
• [Presentation] Imaging cell cycle progression in gastric cancer lymph node metastasis indicates large fraction of proliferating cancer cells (2012)
  • Author(s): Suetsugu A, Mohamed Hassanein, Moriwaki H, Yano S, Toshiyoshi Fujiwara, Bouvet M, Saji S, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
• [Presentation] Color-coded imaging of the pre-metastatic niche in the lung and liver indicates the involvement of cancer-associated fibroblasts (2012)
  • Author(s): Suetsugu A, Momiyama M, Yosuke Osawa, Moriwaki H, Bouvet M, Saji S, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
• [Presentation] Raster-image-correlation spectroscopy of paxillin-GFP-expressing breast cancer cell in vitro and in vivo (2012)
  • Author(s): Suetsugu A, Michelle Digman, Federica Sabatini, Moriwaki H, Saji S, Enrico Gratton, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
• [Presentation] Imaging of the interaction of pancreatic cancer and stellate cells during liver metastasis (2012)
  • Author(s): Suetsugu A, Cynthia Snyder, Moriwaki H, Saji S, Bouvet M, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
• [Presentation] Real-time imaging of inter-cellular communication via exosomes (2012)
  • Author(s): Honma K, Suetsugu A, Ochiya T, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
• [Presentation] Fluorescence lifetime imaging microcopy of extravasating cancer cells in the mouse microenvironment (2012)
  • Author(s): Michelle A. Digman, Suetsugu A, Federica Sabatini, Hoffman RM, Enrico Gratton
  • Organizer: 56th Annual Meeting of the Biophysical Society
  • Place of Presentation: San Diego, California
• [Presentation] RFP-expressing glioma successfully resected in othotopic mouse models using fluorescence-guided surgery. (2012)
  • Author(s): Masashi Momiyama
  • Organizer: World Molecular imaging congress (WMIC)
  • Place of Presentation: Dublin, Ireland
• [Presentation] Non-invasive imaging of orthotopic patient pancreatic tumors in nude mice using fluorescent proteins. (2012)
  • Author(s): Atsushi Suetsugu
  • Organizer: World Molecular imaging congress (WMIC)
  • Place of Presentation: Dublin, Ireland
• [Presentation] In vivo imaging of human pancreatic cancer liver metastasis in orthotopic nude mouse models indicates the importance of pancreatic stellate cells. (2012)
  • Author(s): Atsushi Suetsugu
  • Organizer: World Molecular imaging congress (WMIC)
  • Place of Presentation: Dublin, Ireland
• [Presentation] Cell cycle position and chemoresponse depends on location in tumor
  • Author(s): Yasunori Tome, Michelle A. Digman, Masashi Momiyama, Atsushi Suetsugu, Enrico Gratton, Shuya Yano, Robert M. Hoffman
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 東京
• [Presentation] Comparison of Salmonella typhimurium A1-R and chemotherapy of human-patient pancreatic tumorgrafts
  • Author(s): Yukihiko Hiroshima, Ming Zhao, Yong Zhang, Ali Maawy, Mohamed K. Hassanein, Atsushi Suetsugu, Takashi Chishima, Kuniya Tanaka, Micheal Bouvet, Itaru Endo, Robert M. Hoffman
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 東京
• [Presentation] 当院におけるC型慢性肝炎に対する3剤併用療法の初期治療効果と副作用の検討
  • Author(s): 末次 淳、宮崎恒起、華井竜徳、今井健二、白木 亮、高井光治、大澤陽介、清水雅仁、内木隆文、森脇久隆
  • Organizer: JDDW2013
  • Place of Presentation: 東京
• [Presentation] HIV感染治療開始後に伴うB型肝炎の免疫再構築症候群の検討
  • Author(s): 末次 淳、宮崎恒起、華井竜徳、今井健二、白木 亮、高井光治、清水雅仁、内木隆文、鶴見寿、森脇久隆
  • Organizer: JDDW2013
  • Place of Presentation: 東京
• [Presentation] Paxillin-expressing breast cancer imaged by raster-image-correlation spectroscopy of GFP in vivo and in vitro
  • Author(s): Atsushi Suetsugu
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（札幌）
• [Presentation] シンポジウム 肝組織幹細胞および肝癌幹細胞における表面マーカーCD133の意義
  • Author(s): 末次 淳
  • Organizer: 第99回日本消化器病学会総会
  • Place of Presentation: 城山観光ホテル（鹿児島市）