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Analysis of the toxicity of illegal harbals with approach of pharmacokinetics and toxicology

Research Project

Project/Area Number 24890088
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Legal medicine
Research InstitutionMie University

Principal Investigator

IKEMURA Mayumi  三重大学, 医学(系)研究科(研究院), 助教 (30515490)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords合法ハーブ / 薬物動態 / 乱用薬物 / JWH-203 / MPHP / JWH-203 / MPHP / 分取薄層クロマトグラフ法 / JWH-251
Research Abstract

In this study, we analyze the component of illegal harbals and investigate the correlation among the respiratory intake of illegal harbals, blood concentration and toxicity. We detected the regulated compound,"JWH-203", from the illegal harbals obtained in our laboratory, suggesting that the illegal harbals should contain the regulated compounds. It is suggested that the pharmacokinetics and toxicity of illegal harbals may differ depending on the variety, whereas the component of illegal harbals may not be detected in blood with lethal doses.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (13 results)

All 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (8 results)

  • [Journal Article] An autopsy case of serotonin toxicity resulting from suicidal administrations of fluvoxamine and lithium2014

    • Author(s)
      Haruka Mannou、Mayumi Ikemura、Yasuhisa Nakagawa、Masayuki Nata、Hiromasa Inoue
    • Journal Title

      Rom J Leg Med

      Volume: 22 Pages: 59-62

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute brainstem compression by intratumoral hemorrhages in an intracranial hypoglossal schwannoma2013

    • Author(s)
      Inoue H、Nakagawa Y、Ikemura M、Usugi E、Kiyofuji Y、Nata M
    • Journal Title

      Leg Med (Tokyo)

      Volume: 15(5) Pages: 249-252

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 死体血における簡易CPR検査の利点および問題点2012

    • Author(s)
      鈴木有芽、井上裕匡、中川泰久、池村真弓、臼杵恵梨、那谷雅之
    • Journal Title

      法医学の実際と研究

      Volume: 55 Pages: 91-97

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular-biological analysis of acute lung injury (ALI) induced by heat exposure and/or intravenous administration of oleic acid2012

    • Author(s)
      Inoue H、Nakagawa Y、Ikemura M,、Usugi E、Nata M
    • Journal Title

      Leg Med (Tokyo)

      Volume: 14(6) Pages: 304-308

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The blood concentration and organ distribution of haloperidol at therapeutic and toxic doses in severe fatty liver disease2012

    • Author(s)
      Ikemura M、Nakagawa Y、Shinone K、Inoue H、Nata M
    • Journal Title

      Leg Med (Tokyo)

      Volume: 14(3) Pages: 147-153

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 海外製ゾピクロン製剤の品質検討2013

    • Author(s)
      池村真弓、山本好男、中川泰久、清藤佑馬、臼杵恵梨、那谷雅之、井上裕匡
    • Organizer
      第60回日本法医学会学術近畿地方集会
    • Place of Presentation
      近畿大学(大阪)
    • Year and Date
      2013-11-16
    • Related Report
      2013 Final Research Report
  • [Presentation] serotonin syndromeモデルラットを用いたFluvoxamineの心保護作用とそのメカニズム2013

    • Author(s)
      臼杵恵梨、中川泰久、池村真弓、井上裕匡、清藤佑馬、那谷雅之
    • Organizer
      第35回日本法医学会学術中部地方集会
    • Place of Presentation
      金沢医科大学(石川)
    • Year and Date
      2013-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] スポーツ飲料摂取後の熱暴露による脳幹への影響の分子病態学的検討2013

    • Author(s)
      清藤佑馬、中川泰久、井上裕匡、池村真弓、臼杵恵梨、那谷雅之
    • Organizer
      第20回日本未病システム学会学術総会
    • Place of Presentation
      一橋大学一橋講堂学術総合センター(東京都)
    • Related Report
      2013 Final Research Report
  • [Presentation] 胃内容物に対する簡易薬毒物検査キットInstant View™M-1の信頼性の検討2013

    • Author(s)
      後藤広樹、池村真弓、清藤佑馬、臼杵恵梨、中川泰久、井上裕匡、那谷雅之
    • Organizer
      日本法中毒学会第32年会
    • Place of Presentation
      さわやかちば県民プラザ(千葉県)
    • Related Report
      2013 Final Research Report
  • [Presentation] 熱暴露に対する事前の電解質飲料摂取の有効性の分子病態学的検討2013

    • Author(s)
      中川泰久、井上裕匡、井上考司、平光正典、岡田美紀、臼杵恵梨、清藤佑馬、池村真弓、那谷雅之
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2013 Final Research Report
  • [Presentation] 電解質飲料摂取後の高温暴露に基づく脳幹の分子病態学的検討2013

    • Author(s)
      清藤佑馬、中川泰久、井上裕匡、池村真弓、臼杵恵梨、那谷雅之
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2013 Final Research Report
  • [Presentation] 上腕骨近位端骨髄腔頂の位置および恥骨結合面の性状による年齢推定法の再考2012

    • Author(s)
      池澤宗成、大阪優、中川泰久、井上裕匡、池村真弓、臼杵恵梨、清藤佑馬、那谷雅之
    • Organizer
      第59回日本法医学学術近畿地方集会
    • Place of Presentation
      京都府立医科大学(京都)
    • Year and Date
      2012-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 舌下神経鞘腫内出血による脳幹圧迫の死亡例2012

    • Author(s)
      井上裕匡、中川泰久、池村真弓、臼杵恵梨、清藤佑馬、那谷雅之
    • Organizer
      第34回日本法医学会学術中部地方集会
    • Place of Presentation
      信州大学(長野)
    • Year and Date
      2012-10-13
    • Related Report
      2013 Final Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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