global genetic analysis of inflammatory bowel disease associated with primary immunodeficiency
| Project/Area Number |
24890095
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|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto University |
|---|
Principal Investigator |
KAWAI Tomoki 京都大学, 医学(系)研究科(研究院), 助教 (20631568)
|
|---|
| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 下部消化管学 / 免疫学 / 炎症性腸疾患 / MAIT細胞 / クローン病 / 潰瘍性大腸炎 |
|---|
| Research Abstract |
A role for mucosal associated invariant T (MAIT) cells has recently been reported in several autoimmune diseases, but contribution to inflammatory bowel disease (IBD) has yet to be described. Here, we analyzed the MAIT cells in the peripheral blood of 88 ulcerative colitis patients and 68 Crohn's disease patients, and intestinal mucosae of 5 ulcerative colitis disease patients and 10 Crohn's disease patients. MAIT cells are significantly reduced both in the peripheral blood and the intestinal mucosa of IBD patients. Furthermore, the proportion of MAIT cells producing IL-17 was higher in Crohn's disease patients compared to controls. These results suggest the association of MAIT cells with pathophysiology of IBD.
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Report
(3 results)
Research Products
(4 results)
