global genetic analysis of inflammatory bowel disease associated with primary immunodeficiency

• Project/Area Number: 24890095
• Research Category: Grant-in-Aid for Research Activity start-up
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Kyoto University
• Principal Investigator: KAWAI Tomoki 京都大学, 医学(系)研究科(研究院), 助教 (20631568)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 下部消化管学 / 免疫学 / 炎症性腸疾患 / MAIT細胞 / クローン病 / 潰瘍性大腸炎

Research Abstract

A role for mucosal associated invariant T (MAIT) cells has recently been reported in several autoimmune diseases, but contribution to inflammatory bowel disease (IBD) has yet to be described. Here, we analyzed the MAIT cells in the peripheral blood of 88 ulcerative colitis patients and 68 Crohn's disease patients, and intestinal mucosae of 5 ulcerative colitis disease patients and 10 Crohn's disease patients. MAIT cells are significantly reduced both in the peripheral blood and the intestinal mucosa of IBD patients. Furthermore, the proportion of MAIT cells producing IL-17 was higher in Crohn's disease patients compared to controls. These results suggest the association of MAIT cells with pathophysiology of IBD.

Research Products

• [Journal Article] Japanese Society of Allergology. Japanese guideline for adult asthma 2014. (2014)
  • Author(s): Shiraishi H, Masuoka M, Ohta S, Suzuki S, Arima K, Taniguchi K, Aoki S, Toda S, Yoshimoto T, Inagaki N, Conway SJ, Narisawa Y, Izuhara K.
  • Journal Title: Allergology International Volume: 61 Pages: 207-17
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Heterozygous TREX1 p.Asp18Asn mutation can cause variable neurological symptoms in a family with Aicardi-Goutieres syndrome/familial chilblain lupus (2013)
  • Author(s): Abe J
  • Journal Title: Rheumatology Volume: 52 Pages: 406-408
  • DOI: 10.1093/rheumatology/kes181
  • Peer Reviewed
• [Presentation] IBD患者では有意なMucosal associated invariant T細胞の減量、アポトーシスの亢進が認められる (2014)
  • Author(s): 日衛嶋栄太郎、河合朋樹、仲瀬裕志、鶴山竜昭、森本剛、八角高裕、松浦稔、吉野琢哉、池内浩基、久松理一、河田健二、酒井義治、千葉勉、西小森隆太、平家俊男
  • Organizer: 第51回日本消化器免疫学会
  • Place of Presentation: 京都
• [Presentation] IBD患者では有意なMucosal associated invariant T細胞の減少、アポトーシスの亢進が認められる (2014)
  • Author(s): 日衛嶋栄太郎
  • Organizer: 日本消化器免疫学会
  • Place of Presentation: 京都大学医学部 芝蘭会館