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global genetic analysis of inflammatory bowel disease associated with primary immunodeficiency

Research Project

Project/Area Number 24890095
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionKyoto University

Principal Investigator

KAWAI Tomoki  京都大学, 医学(系)研究科(研究院), 助教 (20631568)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords下部消化管学 / 免疫学 / 炎症性腸疾患 / MAIT細胞 / クローン病 / 潰瘍性大腸炎
Research Abstract

A role for mucosal associated invariant T (MAIT) cells has recently been reported in several autoimmune diseases, but contribution to inflammatory bowel disease (IBD) has yet to be described. Here, we analyzed the MAIT cells in the peripheral blood of 88 ulcerative colitis patients and 68 Crohn's disease patients, and intestinal mucosae of 5 ulcerative colitis disease patients and 10 Crohn's disease patients. MAIT cells are significantly reduced both in the peripheral blood and the intestinal mucosa of IBD patients. Furthermore, the proportion of MAIT cells producing IL-17 was higher in Crohn's disease patients compared to controls. These results suggest the association of MAIT cells with pathophysiology of IBD.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (4 results)

All 2014 2012

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Heterozygous TREX1 p.Asp18Asn mutation can cause variable neurological symptoms in a family with Aicardi-Goutieres syndrome/familial chilblain lupus.2012

    • Author(s)
      Abe J
    • Journal Title

      Rheumatology

      Volume: 52 Issue: 2 Pages: 406-408

    • DOI

      10.1093/rheumatology/kes181

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis and treatment in anhidrotic ectodermal dysplasia with immunodeficiency.2012

    • Author(s)
      Tomoki Kawai
    • Journal Title

      Allergology International

      Volume: 61 Pages: 207-17

    • NAID

      130004477140

    • Related Report
      2012 Annual Research Report
  • [Presentation] IBD患者では有意なMucosal associated invariant T細胞の減量、アポトーシスの亢進が認められる2014

    • Author(s)
      日衛嶋栄太郎、河合朋樹、仲瀬裕志、鶴山竜昭、森本剛、八角高裕、松浦稔、吉野琢哉、池内浩基、久松理一、河田健二、酒井義治、千葉勉、西小森隆太、平家俊男
    • Organizer
      第51回日本消化器免疫学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] IBD患者では有意なMucosal associated invariant T細胞の減少、アポトーシスの亢進が認められる2014

    • Author(s)
      日衛嶋栄太郎
    • Organizer
      日本消化器免疫学会
    • Place of Presentation
      京都大学医学部 芝蘭会館
    • Related Report
      2013 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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