| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Research Abstract |
Intracranial aneurysm (IA) is a major cause of subarachnoid hemorrhage (SAH), the most severe form of stroke.Histologically, IA is characterized as a lesion with excessive degenerative changes of arterial walls. However, the mechanisms regulating such degenerative changes of the media remains to be elucidated. In the present study, we have revealed the crucial role of inflammatory responses in IA formation, especially the degenerative changes of the media, mainly using rodent models of IAs. Further, in series of studies, we have clarified some potential mediators regulating or positively correlated with degeneration, such as lipid accumulation in adventitia of IA walls, prostaglandin F2a-FP signaling cascade and TNF-alpha signaling. In conclusion, the findings from the present study have suggested the role of inflammatory responses in degenerative changes in IA lesions.
|
