Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Research Abstract |
Thanatophoric dysplasia (TD) is a severe skeletal disorder caused by gain-of-function mutations in the fibroblast growth factor receptor-3 (FGFR3) gene. Patients with TD show short limbs and a narrow rib cage caused by abnormal cartilage formation. There are needs for drugs, however the disease mechanism is still unclear. Here, we have generated induced pluripotent stem cells (iPSCs) from fibroblasts obtained from TD-patients. Then, we will understand disease mechanism and screen candidate drugs.
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