Functions of adoptive immune system after injury of the central nervous system and immunomodulatory treatment

• Project/Area Number: 24890113
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Osaka University
• Principal Investigator: ISHII Hiroshi 大阪大学, 大学院・医学系研究科, 助教 (90634171)
• Project Period (FY): 2012 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 中枢神経損傷 / 獲得免疫系 / Th1細胞 / ミクログリア / マクロファージ / 脊髄損傷 / リンパ球 / サイトカイン / RGMa / Tリンパ球 / インターフェロンγ / インターロイキン10 / M2ミクログリア / M2マクロファージ

Research Abstract

We demonstrated that transfer ofproinflammatory Th1 cells unexpectedly promoted functional recovery after spinal cord injury(SCI). The effects of Th1 cells depended on expression of interferon-γ in Th1 cells as well as interleukin 10(IL-10)up-regulation from microglia and macrophages in the injured site. In addition, genetic deletion of IL-10 from Th1 cells abrogated complete effects of Th1 cell transfer.

Research Products

• [Journal Article] Interferon-gamma-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury (2013)
  • Author(s): Ishii H, Tanabe S, Ueno M, Kubo T, Kayama H,Serada S, Fujimoto M, Takeda K, Naka T, and Yamashita T
  • Journal Title: Cell Death and Disease Nature Publishing Group Volume: 4
• [Journal Article] Interferon-gamma-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury. (2013)
  • Author(s): Ishii H
  • Journal Title: Cell Death and Disease Volume: 4
  • Peer Reviewed
• [Journal Article] Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord irljury (2012)
  • Author(s): Ishii H, Jin X, Ueno M, Tanabe S, Kubo T, Serada S, Naka T, Yamashita T
  • Journal Title: Cell Death and Disease Nature Publishing Group Volume: 3
• [Journal Article] Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord lnJury (2012)
  • Author(s): Ishii H, Jin X, Ueno M, Tanabe S, Kubo, Serada S, Naka T. Yamashita T
  • Journal Title: Cell Death Dis Volume: 3 Issue: 8 Pages: e363-e363
  • DOI: 10.1038/cddis.2012.106
  • Peer Reviewed
• [Presentation] RGMa expressed on Th17 cells is enhanced by IL-23 and induces neuronal cell death. (2013)
  • Author(s): Yamashita T
  • Organizer: 日本神経科学会
  • Place of Presentation: 京都
• [Presentation] IFN-_Y and IL-10 are required for neuroprotection by Th1 cells after spinal cord inj ury (2012)
  • Author(s): Ishii H, Kubo T, Naka T, Yamashita T
  • Organizer: Neuroscience 2012, Society for Neuroscience Daily Books Book Six, page43
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 2012-10-17
• [Presentation] IFN-γ and IL-10 are required for neuroprotection by Th1 cells after spinal cord injury. (2012)
  • Author(s): Hiroshi Ishii
  • Organizer: Neuroscience 2012, Society for Neuroscience
  • Place of Presentation: New Orleans, LA, USA
• [Remarks] 大阪大学大学院医学系研究科分子神経科学ホームページ
  • URL: http://www.molneu.med.osaka-u.ac.jp