| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Cohesin complex is composed of four subunits, Smc3, Smc1, Scc3, and Scc1, and has a role in sister chromatid cohesion, which is crucial for accurate chromosome segregation. Cohesin is also known to be involved in chromatin organization by forming chromatin loops at particular loci and regulate gene expression in postmitotic cells. Disruption of cohesin network results in cohesinopathies such as Cornelia de Lange syndrome. These diseases cause higher brain dysfunction, suggesting the role of cohesin in gene regulation rather than chromosome segregation. In this study, we tested the hypothesis that cohesin regulates genome organization and its deficiency leads to higher brain dysfunction.
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