Myelo-derived cells in the ivasion and metastasis of prostate cancer
| Project/Area Number |
24890115
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
FUJITA Kazutoshi 大阪大学, 医学(系)研究科(研究院), 助教 (50636181)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 前立腺癌 / PTEN / 骨髄由来細胞 |
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| Research Abstract |
Using Cre-loxP systems, we created prostate-specific PTEN knockout mice and prostate-specific PTEN/TP53 mice. We are doing the transplantation of bone marrow from GFP-mice. To establish the bone marrow transplantation in mice, we first create the chimera rats which have the transplantion of bone marrow cells derived from GFP rat. After the injury to the prostate by the inflammation or the castration, the prostate of chimera rats were analyzed histologically. We confirmed the myelo-derived stromal cells were infiltrated into the prostate epithelial layers and stroma.
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Report
(3 results)
Research Products
(3 results)
