Enhanced Osteogenesis of iPS Cells by Small Molecules

Research Project

Project/Area Number	24890120
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Prosthetic dentistry
Research Institution	Osaka University
Principal Investigator	KAYASHIMA Hiroki 大阪大学, 歯学部附属病院, 医員 (50632121)
Project Period (FY)	2012-08-31 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	バイオロジー / 再生医療
Research Abstract	The aim of this study was to investigate osteogenic differentiation capacity of iPS cells, and to examine effects of osteoblast-targeting small-molecules on the iPS cell osteogenesis.iPS cells produced robustly mineralized bone nodules that contained abundant calcium phosphate in vitro, and the osteogenesis can be enhanced by small molecules.iPS cell/gel scaffold construct by transplantation into the back of the SCID mouse skin showed apparent new bone formation without tumor formation.

Report

(3 results)