Analyses of predictive factors from hepatitis to cirrhosis using metabolomics

• Project/Area Number: 24890126
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Kobe University
• Principal Investigator: MASAYA Saito 神戸大学, 医学部附属病院, その他 (00631558)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 肝硬変 / 肝線維化 / 肝炎

Research Abstract

Using liver biopsy, hepatitis was induced in mice with coline-deficient diet for 4 weeks, but not in mice without coline-deficient diet. Serum level of taurine decreased in mice with coline-deficient diet for 4 weeks. In mice with coline-deficient diet for 8 weeks, liver tissue showed cirrhosis from hepatitis.
In cirrhotic mice, moreover, serum level of taurine decreased compared with that of hepatitis mice. Therefore, serum taurine would negatively be associated with liver fibrosis in mice. In human as well as mice, serum level of taurine was negatively associated with liver fibrosis. We thought that serum level of taurine would be a predictive marker of liver fibrosis.

Research Products

• [Journal Article] Mutational diversity of NS5A and NS3 during triple therapy (telaprevir, pegylated-interferon-α 2b and ribavirin) for genotype 1b chronic hepatitis C (2014)
  • Author(s): Bai F, Yano Y, Kim SR, Seo Y, Miki A, Saito M, Hirano H, Momose K, Minami A, Hatazawa Y, Hayakumo T, Widasari DI, Rinonce HT, Sugano M, Tani S, Yoon S, Imoto S, Azuma T, Hotta H, Hayashi Y
  • Journal Title: Int J Mol Med Volume: in press Issue: 6 Pages: 1652-1656
  • DOI: 10.3892/ijmm.2014.1706
  • Peer Reviewed
• [Journal Article] Branched-chain amino acid granules improve non-protein respiratory quotient after radiofrequency ablation (2014)
  • Author(s): Masaya Saito, Yoshihiko Yano, Akihiro Minami, Hirotaka Hirano, Kenji Momose, Maki Sugimoto, Masaru Yoshida, Takeshi Azuma
  • Journal Title: Intern Med Volume: (in press)
  • NAID: 130004466403
• [Journal Article] Autoimmune-associated hemophagocytic syndrome originating from autoimmune hepatitis with a successful response to therapy : a case report (2014)
  • Author(s): Masaya Saito, Yoshihiko Yano, Akihiro Minami, Kenji Momose, Hirotaka Hirano, Takashi Yamasaki, Tomoo Itoh, Masaru Yoshida, Takeshi Azuma
  • Journal Title: Intern Med Volume: 53(2) Pages: 103-107
• [Journal Article] Autoimmune-associated hemophagocytic syndrome originating from autoimmune hepatitis with a successful response to therapy: a case report. (2014)
  • Author(s): Masaya Saito, Yoshihiko Yano, Akihiro Minami, Kenji Momose, Hirotaka Hirano,
  • Journal Title: Intern Med Volume: 53 Pages: 103-107
  • Peer Reviewed
• [Journal Article] Branched-chain amino acid granules improve non-protein respiratory quotient after radiofrequency ablation. (2014)
  • Author(s): Masaya Saito, Yoshihiko Yano, Akihiro Minami, Hirotaka Hirano, Kenji Momose, Maki Sugimoto, Masaru Yoshida, Takeshi Azuma.
  • Journal Title: Intern Med Volume: -
  • NAID: 130004466403
  • Peer Reviewed
• [Journal Article] Quantification of Pregenomic RNA and Covalently Closed Circular DNA in Hepatitis B Virus-Related Hepatocellular Carcinoma (2013)
  • Author(s): Fugui Bai, Yoshihiko Yano, Takumi Fukumoto, Atsushi Takebe, Motofumi Tanaka, Kaori Kuramitsu, Nungki Anggorowati, Hanggoro Tri Rinonce, Dewiyani Widasari, Masaya Saito, Hirotaka Hirano, Takanobu Hayakumo, Yasushi Seo, Takeshi Azuma, Yonson Ku, Yoshitake Hayashi
  • Journal Title: Int J Hepatol Volume: - Pages: 849290-849290
  • DOI: 10.1155/2013/849290
  • Peer Reviewed
• [Journal Article] Serum albumin and prothrombin time before entecavir treatment in chronic hepatitis B or cirrhosis are related to amelioration of liver function after treatment (2013)
  • Author(s): Masaya Saito, Yasushi Seo, Yoshihiko Yano, Kenji Momose, Hirotaka Hirano, Masaru Yoshida, Takeshi Azuma
  • Journal Title: Eur J Gastroenterol Hepatol Volume: 25(12) Pages: 1369-76
• [Journal Article] Portal venous tumor growth- type of hepatocellular carcinoma without liver parenchyma tumor nodules : a case report (2013)
  • Author(s): Masaya Saito, Yasushi Seo, Yoshihiko Yano, Keiichiro Uehara, Shigeo Hara, Kenji Momose, Hirotaka Hirano, Hiroshi Yokozaki, Masaru Yoshida, Takeshi Azuma
  • Journal Title: Ann Hepatol Volume: 16(6) Pages: 969-973
• [Journal Article] Reduction in non-protein respiratory quotient is related to overall survival after hepatocellular carcinoma treatment (2013)
  • Author(s): Masaya Saito, Yasushi Seo, Yoshihiko Yano, Kenji Momose, Hirotaka Hirano, Masaru Yoshida, Takeshi Azuma
  • Journal Title: PLoS One Volume: 8 Issue: 3 Pages: e55441-e55441
  • DOI: 10.1371/journal.pone.0055441
  • NAID: 120005603816
  • Peer Reviewed
• [Journal Article] NX-DCP as a novel biomarker would be related to liver function in cirrhotic patients with hepatocellular carcinoma (2013)
  • Author(s): Hirotaka Hirano, Masaya Saito, Yasushi Seo, Yoshihiko Yano, Takeshi Azuma
  • Journal Title: Eur J Gastroenterol Hepatol Volume: 25(6) Pages: 748-749
• [Journal Article] Successful treatment by coil embolization of symptomatic intrahepatic portosystemic venous shunt through a patent ductus venosus in a non-cirrhotic adult : a case report (2013)
  • Author(s): Masaya Saito, Yasushi Seo, Yoshihiko Yano, Kenji Momose, Hirotaka Hirano, Masaru Yoshida, Takeshi Azuma
  • Journal Title: Intern Med Volume: 52(5) Pages: 555-559
• [Journal Article] Serum albumin and prothrombin time before entecavir treatment in chronic (2013)
  • Author(s): Masaya Saito, Yasushi Seo, Yoshihiko Yano, Kenji Momose, Hirotaka Hirano, Masaru Yoshida, Takeshi Azuma.
  • Journal Title: Eur J Gastroenterol Hepatol Volume: 25 Pages: 1369-1376
  • Peer Reviewed
• [Journal Article] Successful treatment by coil embolization of symptomatic intrahepatic portosystemic venous shunt through a patent ductus venosus in a non-cirrhotic adult: a case report (2013)
  • Author(s): Masaya Saito
  • Journal Title: Internal Medicine Volume: -
  • Peer Reviewed
• [Journal Article] NX-DCP as a novel biomarker would be related to liver function in cirrhotic patients with hepatocellular carcinoma (2013)
  • Author(s): Hirotaka Hirano
  • Journal Title: European Journal of Gastroenterology and Hepatology Volume: -
  • Peer Reviewed
• [Journal Article] Portal venous tumor growth- type of hepatocellular carcinoma without liver parenchyma tumor nodules: a case report (2013)
  • Author(s): Masaya Saito
  • Journal Title: Annals of Hepatology Volume: -
  • Peer Reviewed
• [Journal Article] Alteration of non-protein respiratory quotient after hepatocellular carcinoma treatment can be related to des-γ-carboxy prothrombin before treatment (2012)
  • Author(s): Masaya Saito, Yasushi Seo, Yoshihiko Yano, Akira Miki, Kenji Momose, Hirotaka Hirano, Masaru Yoshida, Takeshi Azuma
  • Journal Title: SpringerPlus Volume: 1 Pages: 55-55
• [Journal Article] Ahmed El-Shamy, Hak Hotta, Yoshitake Hayashi, Kobe Hepatitis Therapeutic Group. Mutations in non-structural 5A and rapid viral response to pegylated interferon-α-2b plus ribavirin therapy are associated with therapeutic efficacy in patients with genotype 1b chronic hepatitis C (2012)
  • Author(s): Yoshihiko Yano, Yasushi Seo, Akira Miki, Masaya Saito, Hirotaka Kato, Ken-Ichi Hamano, Manabu Oya, Sachiko Ouchi, Takashi Fujisawa, Hajime Yamada, Yukimasa Yamashita, Satoshi Tani, Shigeya Hirohata, Seitetsu Yoon, Naoto Kitajima, Kazunari Kitagaki, Akira Kawara, Takatoshi Nakashima, Hosai Yu, Tetsuo Maeda, Takeshi Azuma
  • Journal Title: Int J Mol Med Volume: 30(5) Pages: 1048-1052
• [Journal Article] A Hepatocellular Carcinoma Developed Following 18 Years from Sustained Virological Response to Interferon Therapy in a Patient with Chronic Hepatitis C : Case Report and Literature Review (2012)
  • Author(s): Masaya Saito, Yasushi Seo, Yoshihiko Yano, Akira Miki, Yukiko Morinaga, Tomoo Itoh, Masaru Yoshida, Takeshi Azuma
  • Journal Title: Clin J Gastroenterol Volume: 5(2) Pages: 119-126
• [Journal Article] A high value of serum des-γ-carboxy prothrombin before hepatocellular carcinoma treatment can be associated with long-term liver dysfunction after treatment (2012)
  • Author(s): Masaya Saito, Yasushi Seo, Yoshihiko Yano, Akira Miki, Masaru Yoshida, Takeshi Azuma
  • Journal Title: J Gastroenterol Volume: 47(10) Pages: 1134-1142
  • NAID: 10031122102
• [Journal Article] Sonazoid-enhanced ultrasonography and Ga-EOB-DTPA-enhanced MRI of hepatic inflammatory pseudotumor : a case report (2012)
  • Author(s): Masaya Saito, Yasushi Seo, Yoshihiko Yano, Akira Miki, Yukiko Morinaga, Tomoo Itoh, Masaru Yoshida, Takeshi Azuma
  • Journal Title: Intern Med Volume: 51(7) Pages: 723-6
  • NAID: 130002061848
• [Journal Article] Short-term reductions in non-protein respiratory quotient and prealbumin can be associated with the long-term deterioration of liver function after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma (2012)
  • Author(s): Masaya Saito, Yasushi Seo, Yoshihiko Yano, Akira Miki, Masaru Yoshida, Takeshi Azuma
  • Journal Title: J Gastroenterol Volume: 47(6) Pages: 704-14
  • NAID: 10030802800
• [Journal Article] Liver dysfunction and survival in hepatocellular carcinoma treated by transarterial chemoembolization (2012)
  • Author(s): Masaya Saito, Yasushi Seo, Yoshihiko Yano, Akira Miki, Kenji Momose, Hirotaka Hirano, Masaru Yoshida, Takeshi Azuma
  • Journal Title: Aliment Pharmacol Ther Volume: 35(7) Pages: 861-2
• [Journal Article] Alteration of non-protein respiratory quotient after hepatocellular carcinoma treatment can be related to des-γ-carboxy prothrombin before treatment (2012)
  • Author(s): Masaya Saito
  • Journal Title: SpringerPlus Volume: 1 Issue: 1 Pages: 55-55
  • DOI: 10.1186/2193-1801-1-55
  • Peer Reviewed
• [Presentation] 肝細胞癌の新規腫瘍マーカーNX-PVKA-Rはアルコールの影響を受けにくい (2013)
  • Author(s): 斉藤 雅也
  • Organizer: 日本肝臓学会総会
  • Place of Presentation: 東京
• [Presentation] TACE後早期の肝代謝の変化は肝細胞癌患者の生命予後に関わっている (2013)
  • Author(s): 斉藤 雅也
  • Organizer: 日本肝臓学会総会
  • Place of Presentation: 東京
• [Presentation] TV投与前の血清AlbとPT%値はB型慢性肝炎/肝硬変の肝機能改善に関わっている (2013)
  • Author(s): 斉藤 雅也
  • Organizer: JDDW 2014
  • Place of Presentation: 東京
• [Presentation] BCAA顆粒は肝細胞癌患者のRFA治療後における肝機能改善だけでなく蛋白エネルギー代謝改善にも関わっている (2013)
  • Author(s): 斉藤 雅也
  • Organizer: JDDW 2014
  • Place of Presentation: 東京
• [Presentation] ステロイド治療が奏功した自己免疫性肝炎が原因となった自己免疫関連血球貪食症候群の1例 (2013)
  • Author(s): 斉藤 雅也
  • Organizer: 日本肝臓学会西部会
  • Place of Presentation: 岐阜