Biomarker discovery against early stage colorectal cancer by comprehensive metabolite profiling

Research Project

Project/Area Number	24890127
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Laboratory medicine
Research Institution	Kobe University
Principal Investigator	YOSHIE Tomoo 神戸大学, 医学(系)研究科(研究院), 特命助教 (10631559)
Project Period (FY)	2012-08-31 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	大腸がん / 代謝物 / プロファイリング / メタボローム解析 / メタボロミクス / 質量分析
Research Abstract	In this study, we performed metabolome analysis for colorectal cancer, and then searched for the reliable biomarker candidates against colorectal cancer. From the experiments using serum and colorectal tissues of APCmin/+ mice and colorectal cancer patients, it was demonstrated that the pathogenesis of colorectal cancer leads to the alterations in levels of the metabolites related to energy metabolism and the increases in levels of lyso-phosphatidylcholine and lyso-phosphatidylethanolamine. These metabolites are considered as the reliable biomarker candidates against colorectal cancer.