Assessment of three-dimensional micro-beam radiation therapy
| Project/Area Number |
24890128
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | マイクロビームX線 / 放射光 / SPring-8 / シンクロトロン / 放射線治療 / マイクロビーム |
|---|
| Research Abstract |
Synchrotron X-ray beams permit the delivery of very high radiation doses to tumors in a single fraction using arrays of microplanar X-ray beams. Microplanar beam (MPB) radiation is, at present, an experimental approach that has produced, in single exposures, exceptionally high tolerance in the normal tissues while preferentially damaging malignant tumors. In this study, we have challenged to evaluate normal tissue tolerance and mortality by MPB radiation to mouse brain with comparing to broad beam from the same radiation source.
In the experimental setting, 50% and 100% lethal dose by the 200 micrometer spacing MPB beam were 600 Gy and 720Gy, while those by the broad beam were 80 Gy and 96 Gy. Beam paths by MPB irradiation were recognized as bands of cell with hyperchromatic. Micro or partial cerebral hemorrhage was shown in the dead mice brain from both groups.Our results indicated that the MPB enable to deliver extremely high doses without loss of normal tissue function.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Patterns of failure after multimodal treatments for high-grade glioma : effectiveness of MIB-1 labeling index2012
Author(s)
Uehara K, Sasayama T, Miyawaki D, Nishimura H, Yoshida K, Okamoto Y, Mukumoto N, Akasaka H, Nishihara M, Fujii O, Soejima T, Sugimura K, Kohmura E, Sasaki R
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Journal Title
Radiation Oncology
Volume: 7
Pages: 104-104
Related Report
Peer Reviewed
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[Presentation] 眼瞼周囲皮膚癌に対する新規眼球シールド使用時の線量分布の検討2014
Author(s)
椋本成俊,宮脇大輔,赤坂浩亮,王天縁,清水康之,上薗玄,吉田賢史,江島泰生,佐々木良平,吉田直碁,表田真弓,西谷隆治,南利明青,山裕一
Organizer
第306回公益社団法人日本医学放射線学会関西地方会(第378回レントゲンアーベント)
Place of Presentation
大阪、ホテルエルセラーン大阪
Year and Date
2014-02-15
Related Report
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[Presentation] A Novel Radiosensitizor of the Functional Food Component, Monogalactosyl diacylglycerol (MGDG) from Spinach, Enhanced the Cytotoxic Effects for the Pancreatic Cancer In Vitro and In Vivo2013
Author(s)
H. Akasaka, R. Sasaki, N. Mukumoto, M. Nakayama, N.S. Sulaiman, D. Miyawaki, K. Yoshida, Y. Ejima, Y. Mizushina
Organizer
55th Annual meeting ASTRO
Place of Presentation
Atlanta, GA
Related Report
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