| Project/Area Number |
24890128
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | マイクロビームX線 / 放射光 / SPring-8 / シンクロトロン / 放射線治療 / マイクロビーム |
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| Research Abstract |
Synchrotron X-ray beams permit the delivery of very high radiation doses to tumors in a single fraction using arrays of microplanar X-ray beams. Microplanar beam (MPB) radiation is, at present, an experimental approach that has produced, in single exposures, exceptionally high tolerance in the normal tissues while preferentially damaging malignant tumors. In this study, we have challenged to evaluate normal tissue tolerance and mortality by MPB radiation to mouse brain with comparing to broad beam from the same radiation source.
In the experimental setting, 50% and 100% lethal dose by the 200 micrometer spacing MPB beam were 600 Gy and 720Gy, while those by the broad beam were 80 Gy and 96 Gy. Beam paths by MPB irradiation were recognized as bands of cell with hyperchromatic. Micro or partial cerebral hemorrhage was shown in the dead mice brain from both groups.Our results indicated that the MPB enable to deliver extremely high doses without loss of normal tissue function.
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