| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
BMP family proteins are widely used for biological research and medical application because of their ability to induce bone morphogenesis at adult homeostasis and differentiation of epidermis and dorsal neural tube at early development. Utilizing growth factors that stimulate bone morphogenesis with a bone implant is a promising approach in regenerative medicine. We create a fusion protein consisting of bone morphologic protein-4 and a collagen-binding domain polypeptide of fibronectin. This fusion protein (CBD-BMP4), produced by a baculovirus expression system, exhibited much strong collagen binding activity. The aim of this study is to examine the effect of this fusion protein for repair of bone defect.
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