| Project/Area Number |
24890135
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
AKIYAMA Kentaro 岡山大学, 医歯(薬)学総合研究科, 助教 (70423291)
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| Research Collaborator |
KUBOKI Takuo 岡山大学, 大学院医歯薬学総合研究科, 教授 (00225195)
ONO Mitsuaki 岡山大学, 大学院医歯薬学総合研究科, 助教 (60613156)
OSHIMA Masamitsu 岡山大学, 大学院医歯薬学総合研究科, 助教 (00548307)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯髄幹細胞 / 神経疾患 / 幹細胞移植治療 / 実験的自己免疫性脳炎 / 抑制性T細胞 / 免疫寛容 / 全身性神経疾患 |
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| Research Abstract |
In this study, we evaluated the therapeutic effect of bone marrow derived mesenchymal stem cells (BMMSCs) or dental pulp stem cells (DPSCs) systemic injection on experimental autoimmune encephalomyelitis (EAE) model mice. In the clinical evaluation, both BMMSCs and DPSCs showed significant therapeutic effect including hind leg paralysis. However, BMMSCs injected group showed, in terms of immunological evaluation, higher up regulation of regulatory T cells (Tregs) in peripheral blood after 40days from EAE induction compare to DPSCs injected group.
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