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Elucidation of of non-alcoholic steatohepatitis exacerbation mechanism by dental infection and effects of dental treatment

Research Project

Project/Area Number 24890138
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionHiroshima University

Principal Investigator

FURUSHO Hisako  広島大学, 医歯薬保健学研究院(歯), 助教 (00634461)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsP.gingivalis / 歯性感染 / NASH / 免疫 / 歯科処置 / LPS / E.coli / パルミチン酸 / 肝構成細胞 / 炎症性サイトカイン
Research Abstract

Effect of Porphyromonas gingivalis (P.g.) on non-alcoholic steatohepatitis (NASH) were examined. Various bacterial components (lipopolysaccharaide;LPS, flagellin and DNA) activate natural immune pathways through TLR2, 4, 5 and 9, resulting in upregulation of inflammatory cytokine expression and inflammasome activation . In fatty liver, showing upreglation TLR2 expression, the increased sensitivity of P.g.-LPS, which is TLR2 ligand, may cause stronger pathogenesis. Moreover, elimination of P.g.-odontogenic infection in P.g.-infected / high fat diet induced NASH mouse model reduced inflammatory cytokines expression and inflammatory cytokines expression and inflammatory cytokines expression and inflammation in liver. It indicates that dental therapy may have beneficial impact on management of NASH.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (4 results)

All 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice2013

    • Author(s)
      FurushoH,Miyauchi M,Hyogo H,Inubushi T,Ao M,Ouhara K,Hisatune J,Kurihara H,Sugai M,Hayes CN,Nakahara T,Akikata H,Takahashi S,Chayama K,Takata T
    • Journal Title

      J Gastroenterol

      Volume: 48(11) Issue: 11 Pages: 1259-70

    • DOI

      10.1007/s00535-012-0738-1

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice2013

    • Author(s)
      Hisako Furusho
    • Journal Title

      Journal of Gastroenterology

      Volume: 48 Pages: 1259-1270

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effect of Porphyromonas gingivalis on the progression non-alcoholic steatohepatitis2013

    • Author(s)
      FurushoH,Miyauchi M,Ao M,Inubushi T,Takata T
    • Organizer
      International Association of Dental Research General Session
    • Place of Presentation
      Seattle
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of Porphyromonas gingivalis on the progression non-alcoholic steatohepatitis.2013

    • Author(s)
      Hisako Furusho
    • Organizer
      国際歯科学研究会(IADR)
    • Place of Presentation
      シアトル(アメリカ合衆国)
    • Related Report
      2012 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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