Preventive mechanisms of Epicatechin against cardiovascular event and examination of the action in the living body
| Project/Area Number |
24890143
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | エピカテキン |
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| Research Abstract |
It is suggested that minimal chronic inflammation caused by periodontal disease can become the arteriosclerotic exacerbation factor. On the other hand, it is reported by ingestion of the dark cocoa that a cardiovascular event incidence decreases, and a cardiovascular event suppressant effect of epicatechin(EC) which is the chief ingredient attracts attention. I paid my attention to Adipocyte-macrophage interaction and, in this study, examined the molecular mechanism of the cardiovascular event suppressant effect by the EC. As a result of having analyzed the change of inflammatory related molecules when I added LPS stimulation to the co-cultures, I was able to confirm the producing decrease of inflammatory related molecules by adding EC.
These results suggested the possibility that a cardiovascular event incidence decreased by anti-inflammatory effect of the EC.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] The Inflammation-lipocalin2 axis may contribute to the development of chronic kidney disease2014
Author(s)
Hashikata A, Yamashita A, Suzuki S, Nagayasu S, Shinjo T, Taniguchi A, Fukushima M, Nakai Y, Nin K, Watanabe N, Asano T, Abiko Y, Kushiyama A, Nagasaka S, Nishimura F. Nephrol
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Journal Title
Dial Transplant
Volume: 29(3)
Pages: 611-8
Related Report
Peer Reviewed
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[Journal Article] Smoking and adipose tissue inflammation suppress leptin expression in Japanese obese males : Potential mechanism of resistance to weight loss among Japanese obese smokers2012
Author(s)
Shintaro Nagayasu, Shigeki Suzuki, Akiko Yamashita, Ataru Taniguchi, Mitsuo Fukushima, Yoshikatsu Nakai, Naoya Watanabe, Shoichiro Nagasaka, Daisuke Yabe, Kazuko Nin, Fusanori Nishimura
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Journal Title
Tobacco Induced Diseases
Volume: 10
Pages: 3-3
Related Report
Peer Reviewed
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[Journal Article] Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation : potential link with metabolic complications2012
Author(s)
Hideo Nakarai, Akiko Yamashita, Shintaro Nagayasu, Misaki Iwashita,Sonoko Kumamoto, Hideki Ohyama, Masaki Hata, Yoshihiko Soga, Akifumi Kushiyama, Tomoichiro Asano, Yoshimitsu Abiko
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Journal Title
Fusanori Nishimura. Innate Immun
Volume: 18(1)
Pages: 164-70
Related Report
Peer Reviewed
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