Role of fatty acid binding proteins for regulation of neural plasticity

• Project/Area Number: 24890144
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Yamaguchi University
• Principal Investigator: YAMAMOTO YUI 山口大学, 医学(系)研究科(研究院), 助教 (80635087)
• Research Collaborator: OWADA Yuji 山口大学, 大学院医学系研究科, 教授 (20292211)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: FABP / 多価不飽和脂肪酸 / 高次脳機能

Research Abstract

In this study, we examined the role of fatty asid binding proteins (FABPs) in the regulation of cellular signaling transduction, mainly by using FABP gene ablated mice. The following results have been so far obtained: 1. brain-type FABP (FABP7) and epidermal-type FABP (FABP5) are differentially expressed in oligodendrocyte lineage cells and regulate their proliferation and/or differentiation(Sharifi et al., Cell and Tissue Res 2013). 2. heart-type FABP (FABP3) gene ablation in mice resulted in altered cognitive and emotional behaviors with the decrease of PUFA uptake into the brain. Basal GABA release was significantly increased in the contex of FABP3 gene ablated mice, while glutamate release was significantly decreased compared with wild-type mice.

Research Products

• [Journal Article] Donepezil rescues the medical septum cholinergic neurons via nicotinic ACh receptor stimulation in olfactory bulbectomized mice (2013)
  • Author(s): Yamamoto Y. and Fukunaga K
  • Journal Title: Advances in Alzheimer's Disease Volume: 2 Pages: 161-170
  • Peer Reviewed
• [Journal Article] Differential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells (2013)
  • Author(s): Sharifi, K., Ebrahimi, M., Kagawa, Y., Islam, A., Tuerxun, T., Yasumoto, Y., Hara, T., Yamamoto Y., Miyazaki, H., Tokuda, N., Yoshikawa, T. and Owada, Y
  • Journal Title: Cell and Tissue Res Volume: 354 Pages: 683-695
  • Peer Reviewed
• [Journal Article] Oral L-citrulline administration improves memory deficits following transient brain ischemia through cerebrovascular protection (2013)
  • Author(s): Yabuki Y, Shioda N, Yamamoto Y, Shigano M, Kumagai K, Morita M, Fukunaga K
  • Journal Title: Brain Res Volume: 1520 Pages: 157-167
  • Peer Reviewed
• [Journal Article] Stimulation of the sigma-1 receptor by DHEA enhances synaptic efficacy and neurogenesis in the hippocampal dentate gyrus of olfactory bulbectomized mice (2013)
  • Author(s): Moriguchi S, Shinoda Y, Yamamoto Y, Sasaki Y, Miyajima K, Tagashira H, Fukunaga K
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] Novel cognitive enhancer ST101 enhances acetylcholine release in mouse dorsal hippocampus through T-type voltage-gated calcium channel stimulation (2013)
  • Author(s): Yamamoto Y, Shioda N, Han F, Moriguchi S, Fukunaga K
  • Journal Title: J Pharmacol Sci Volume: 12 Pages: 212-226
  • NAID: 10031165466
  • Peer Reviewed
• [Journal Article] Donepezil rescues the medial septum cholinergic neurons via nicotinic ACh receptor stimulation in olfactory bulbectomized mice. (2013)
  • Author(s): Yamamoto, Y. and Fukunaga, K.
  • Journal Title: Advances in Alzheimer's Disease Volume: 2 Issue: 04 Pages: 161-170
  • DOI: 10.4236/aad.2013.24021
  • Peer Reviewed
• [Journal Article] Differential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells (2013)
  • Author(s): Sharifi K, Yoshikawa
  • Journal Title: Cell and Tissue Research Volume: 354 Issue: 3 Pages: 683-695
  • DOI: 10.1007/s00441-013-1730-7
  • Peer Reviewed
• [Journal Article] Oral L-citrulline administration improves memory deficits following transient brain ischemia through cerebrovascular protection (2013)
  • Author(s): Yabuki Y, Shioda N, Yamamoto Y, Shigano M, Kumagai K, Morita M, Fukunaga K
  • Journal Title: Brain Res. Volume: 1520 Pages: 157-67
  • DOI: 10.1016/j.brainres.2013.05.011
  • Peer Reviewed
• [Journal Article] Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Effic acy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice. (2013)
  • Author(s): Shigeki Moriguchi
  • Journal Title: PLoS One. Volume: 8(4) Issue: 4 Pages: e60863-e60863
  • DOI: 10.1371/journal.pone.0060863
  • Peer Reviewed
• [Journal Article] The novel cognitive enhancer ST101 enhances acetylcholine release in mouse dorsal hippocampus through T-type voltage-gated calcium channel stimulation. (2013)
  • Author(s): 山本由似
  • Journal Title: Journal of Pharmacological Sciences Volume: 121 Pages: 212-226
  • NAID: 10031165466
  • Peer Reviewed
• [Journal Article] The T-type voltage-gated calcium channel as a molecular target of the novel cognitive enhancer ST101: enhancement of long-term potentiation and CaMKII autophosphorylation in rat cortical slices (2012)
  • Author(s): Moriguchi S, Shioda N, Yamamoto Y, Tagashira H, Fukunaga K
  • Journal Title: J Neurochem Volume: 121 Pages: 44-53
  • Peer Reviewed
• [Presentation] 帯状皮質の脂肪酸結合蛋白質はGABA作動性ニューロン調節を介して神経可塑性に関与する (2014)
  • Author(s): 山本由似、徳田信子、澤田知夫、福永浩司、大和田祐二
  • Organizer: 第119回日本解剖学会総会・全国学術集会
  • Place of Presentation: 自治医科大学、栃木
  • Year and Date: 2014-03-28
• [Presentation] FABP3 deficiency in mouse placenta impaired fatty acid transport form mother to fetus (2014)
  • Author(s): Islam, A., Sharifi, K., Ebrahimi, M., Kagawa, Y., Sawada, T., Yamamoto Y., Yasumoto, Y., Miyazaki, H., Suzuki, R. and Owada, Y
  • Organizer: 第119回日本解剖学会総会・全国学術集会
  • Place of Presentation: 自治医科大学、栃木
  • Year and Date: 2014-03-28
• [Presentation] FABP3は介在神経のGAD67発現を調節する (2014)
  • Author(s): 山本由似、福永浩司、大和田祐二
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学、熊本
  • Year and Date: 2014-03-28
• [Presentation] FABP3は帯状皮質神経細胞におけるGABAシグナルを調節する (2014)
  • Author(s): 山本由似、福永浩司、大和田祐二
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 東北大学、宮城
  • Year and Date: 2014-03-19
• [Presentation] FABP7 is involved in epigenetic modification in astrocytes (2013)
  • Author(s): Kagawa, Y., Yasumoto, Y., Sharifi, K., Ebrahimi, M., Islam, A., Miyazaki, H., Kawamura, S., Yamamoto Y., Yoshikawa, T., Kogo, H., Sato, S., Sugino, N., Fujimoto, T., Owada, Y
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸ポートピアホテル、神戸
  • Year and Date: 2013-12-04
• [Presentation] 脂肪酸結合タンパク質研究から見えてくる神経精神疾患 (2013)
  • Author(s): 山本由似
  • Organizer: 第18回ERATOタンパク質関連情報交換会
  • Place of Presentation: 大阪大学、大阪
  • Year and Date: 2013-11-22
• [Presentation] Fatty acid binding protein 3 (FABP3) regulates cognitive function and anxiety behaviors (2013)
  • Author(s): Yamamoto Y., Sharifi, K., Islam, A., Ebrahimi, M., Kagawa, Y., Yasumoto, Y., Miyazaki, H., Kawamura, S., Sawada, T., Tokuda, N., Fukunaga, K., Owada, Y
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-14
• [Presentation] FABP7 is expressed in astrocytes and regulates the excitatory synapse formation in mouse cerebral cortex (2013)
  • Author(s): Ebrahimi, M., Sharifi, K., Kagawa, Y., Islam, A., Yasumoto, Y., Miyazaki, H., Kawamura, S., Yamamoto Y., Sawada, T., Yoshikawa, T., Owada, Y
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-14
• [Presentation] (2013)
  • Author(s): Yasumoto, Y., Sadahiro, H., Sharifi, K., Kagawa, Y., Ebrahimi, M., Islam, A., Miyazaki, H., Kawamura, S., Yamamoto Y., Sawada, T., Suzuki, M., Owada, Y
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-14
• [Presentation] 脂肪酸結合蛋白質FABP3による情動・認知行動調節メカニズム (2013)
  • Author(s): 山本由似、徳田信子、澤田知夫、福永浩司、大和田祐二
  • Organizer: 日本解剖学会第68回中国・四国支部学術集会
  • Place of Presentation: 鳥取大学、鳥取
  • Year and Date: 2013-10-20
• [Presentation] Fatty acid-binding protein 7 (FABP7) regulates lipid raft formation in astrocytes (2013)
  • Author(s): Kagawa, Y., Ebrahimi, M., Sharifi, K., Islam, A., Yasumoto, Y., Miyazaki, H., Kawamura, S., Yamamoto Y., Sawada, T., Tokuda, T., Kogo, H., Fujimoto, T., Yoshikawa, T., Owada, Y
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2013-09-13
• [Presentation] 脳型脂肪酸結合蛋白質(FABP7)は脂質ラフト形成を制御する (2013)
  • Author(s): 香川慶輝、Ebrahimi Majid、Sharifi Kazem、安本有希、宮崎啓史、Islam Ariful、山本由似、河村沙樹、原伯徳、澤田知夫、大和田祐二
  • Organizer: 第119回山口大学医学会学術講演会
  • Place of Presentation: 山口大学、宇部
  • Year and Date: 2013-09-07
• [Presentation] Fatty acid binding protein 3 (FABP3)-knock-out induced cognitive dysfunction and anxiety phenotype (2013)
  • Author(s): Yamamoto Y., Owada, Y., Fukunaga, K
  • Organizer: 第11回世界生物学的精神医学会国際会議
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2013-06-24
• [Presentation] 脂肪酸結合タンパク質FABP3欠損マウスにおける認知機能及び情動行動異常の神経機序 (2013)
  • Author(s): 山本由似、福永浩司、大和田祐二
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2013-06-22
• [Presentation] 脂肪酸結合蛋白質FABP3欠損マウスにおける情動行動とシグナル伝達異常 (2013)
  • Author(s): 山本由似、徳田信子、澤田知夫、福永浩司、大和田祐二
  • Organizer: 第118回日本解剖学会総会・全国学術総会
  • Place of Presentation: サンポートホール高松・かがわ国際会議場、高松
  • Year and Date: 2013-03-30
• [Presentation] シグナル伝達と情動行動への脂肪酸結合蛋白質FABP3の関与 (2013)
  • Author(s): 山本由似、大和田祐二、福永浩司
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場、福岡
  • Year and Date: 2013-03-21
• [Presentation] 脂肪酸結合タンパク質FABPの精神疾患への関与 (2013)
  • Author(s): 山本由似、大和田祐二
  • Organizer: 山口大学研究推進体「ストレス」成果報告シンポジウム
  • Place of Presentation: 山口大学、宇部
  • Year and Date: 2013-02-08
• [Presentation] 脂肪酸結合蛋白質FABP3欠損マウスにおける情動行動とCaMキナーゼ活性の異常 (2012)
  • Author(s): 山本由似、塩田倫史、大和田祐二、福永浩司
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸コンベンションセンター、神戸
  • Year and Date: 2012-09-30
• [Presentation] FABP3は介在神経のGAD67発現を調節する
  • Author(s): 山本由似、福永浩司、大和田祐二
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学（熊本）
• [Presentation] 帯状皮質の脂肪酸結合蛋白質はGABA作動性ニューロン調節を介して神経可塑性に関与する
  • Author(s): 山本由似、徳田信子、澤田知夫、福永浩司、大和田祐二
  • Organizer: 第119回日本解剖学会総会・全国学術集会
  • Place of Presentation: 自治医科大学キャンパス（栃木）
• [Presentation] FABP3は帯状皮質神経細胞におけるGABAシグナルを調節する
  • Author(s): 山本由似、福永浩司、大和田祐二
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 東北大学（宮城県仙台市）
• [Presentation] 脂肪酸結合タンパク質研究から見えてくる神経精神疾患
  • Author(s): 山本由似
  • Organizer: 第18回ERATOタンパク質関連情報交換会
  • Place of Presentation: 大阪大学（大阪）
  • Invited
• [Presentation] Fatty acid binding protein 3 (FABP3) regulates cognitive function and anxiety behaviors.
  • Author(s): Yamamoto, Y., Sharifi, K., Islam, A., Ebrahimi, M., Kagawa, Y., Yasumoto, Y., Miyazaki, H., Kawamura, S., Sawada, T., Tokuda, N., Fukunaga, K. and Owada, Y.
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego （USA）
• [Presentation] Fatty acid binding protein 3 (FABP3) knock out induced cognitive dysfunction and an anxiety phenotype.
  • Author(s): Yamamoto, Y., Owada, Y. and Fukunaga, K.
  • Organizer: WFSBP Congress 2013
  • Place of Presentation: 京都国際会館（京都）
• [Presentation] 脂肪酸結合蛋白質 FABP3 欠損マウスにおける情動行動とシグナル伝達異常
  • Author(s): 山本由似
  • Organizer: 第118回日本解剖学会総会
  • Place of Presentation: サンポートホール高松・かがわ国際会議場（香川）
• [Presentation] シグナル伝達と情動行動への脂肪酸結合蛋白質 FABP3 の関与
  • Author(s): 山本由似
  • Organizer: 第86回 日本薬理学会年会
  • Place of Presentation: 福岡国際会議場(福岡）
• [Presentation] 精神疾患を理解するための脂肪酸結合タンパク質研究
  • Author(s): 山本由似
  • Organizer: 山口大学研究推進体「ストレス」成果報告シンポジウム
  • Place of Presentation: 山口大学医学部霜仁会館（山口）
• [Presentation] 脂肪酸結合蛋白質ＦＡＢＰ3欠損マウスにおける情動行動とCaMキナーゼ活性の異常
  • Author(s): 山本由似
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸コンベンションセンター（神戸）
• [Presentation] 脂肪酸結合蛋白質ＦＡＢＰ3欠損マウスにおける不安様行動とシグナル伝達異常
  • Author(s): 山本由似
  • Organizer: 第22回日本臨床精神神経薬理学会・第42回日本神経精神薬理学会合同年会
  • Place of Presentation: 宇都宮東武ホテルグランデ（栃木県）
• [Remarks]
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~org-anat/
• [Remarks] 山口大学大学院医学系研究科 器官解剖学分野
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~org-anat/
• [Remarks] 山口大学大学院 医学系研究科 器官解剖学分野
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~org-anat/