Glomerular endothelial insulin signaling in diabetic nephropathy

• Project/Area Number: 24890148
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: MIMA Akira 徳島大学, ヘルスバイオサイエンス研究部, 助教 (00432401)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 糖尿病性腎症 / インスリンシグナル / 血管内皮細胞

Research Abstract

Insulin-induced phosphorylation of Akt and eNOS were significantly increased in primary lung endothelial cells from endothelial cells specific overexpression of IRS1 transgenic mice (EC-IRS1 Tg). Further, in vivo study, increases in these phosphorylation were recognized in left ventricule, femoral artery and muscle. Diabetes-induced increases in urinary 8-OHdG and mesangial expansion were ameliorated in EC-IRS1 Tg.

Research Products

• [Journal Article] Use of a polysulfone hemodialysis membrane may prevent recurrent posterior reversible encephalopathy syndrome in a patient undergoing hemodialysis (2014)
  • Author(s): Mima A, Matsubara T, Endo S, Murakami T, Hashimoto Y
  • Journal Title: Int Urol Nephrol Volume: 46 Pages: 255-60
  • Peer Reviewed
• [Journal Article] Induction of Vascular Insulin Resistance, Endothelin-1 Expression, and acceleration of atherosclerosis by the overexpression of protein kinase Cβisoform in the endothelium (2013)
  • Author(s): Li Q, Park K, Li C, Rask-Madsen C, Mima A, Qi W, Mizutani K, Huang PL, King GL
  • Journal Title: Circ Res Volume: 113 Pages: 418-27
  • Peer Reviewed
• [Journal Article] Serine Phosphorylation Sites on IRS2 Activated by Angiotensin II and Protein Kinase C To Induce Selective Insulin Resistance in Endothelial Cells (2013)
  • Author(s): Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL
  • Journal Title: Mol Cell Biol Volume: 333 Pages: 3227-3241
  • Peer Reviewed
• [Journal Article] Dual involvement of growth arrest-specific gene 6 in the early phase of human IgA nephropathy (2013)
  • Author(s): Nagai K, Miyoshi M, Kake T, Fukushima N, Matsuura M, Shibata E, Yamada S, Yoshikawa K, Kanayama HO, Fukawa T, Yamaguchi K, Izaki H, Mima A, Abe N, Araoka T, Murakami T, Kishi F, Kishi S, Tominaga T, Moriya T, Abe H, Doi T
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] Diabetic nephropathy : protective factors and a new therapeutic paradigm (2013)
  • Author(s): Mima A
  • Journal Title: J Diabetes Complications Volume: 27 Pages: 526-30
  • Peer Reviewed
• [Journal Article] Inflammation and oxidative stress in diabetic nephropathy : new insights on its inhibition as new therapeutic targets (2013)
  • Author(s): Mima A
  • Journal Title: J Diabetes Res Volume: 該当なし Pages: 207140-207140
  • DOI: 10.1155/2014/207140
  • Peer Reviewed / Open Access
• [Journal Article] Inflammation and oxidative stress in diabetic nephropathy: new insights on its inhibition as new therapeutic targets (2013)
  • Author(s): Mima A
  • Journal Title: J Diabetes Res Volume: - Pages: 1-8
  • DOI: 10.1155/2013/248563
  • Peer Reviewed
• [Journal Article] Diabetic nephropathy: protective factors and a new therapeutic paradigm (2013)
  • Author(s): Mima A
  • Journal Title: J Diabetes Complications Volume: 27 Issue: 5 Pages: 526-530
  • DOI: 10.1016/j.jdiacomp.2013.03.003
  • Peer Reviewed
• [Journal Article] Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-β isoform in the endothelium (2013)
  • Author(s): Li Q, Park K, Li C, Rask-Madsen C, Mima A, Qi W, Mizutani K, Huang P, King GL
  • Journal Title: Circ Res Volume: 113 Issue: 4 Pages: 418-427
  • DOI: 10.1161/circresaha.113.301074
  • Peer Reviewed
• [Journal Article] Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells (2013)
  • Author(s): Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL
  • Journal Title: Mol Cell Biol Volume: 33 Issue: 16 Pages: 418-427
  • DOI: 10.1128/mcb.00506-13
  • Peer Reviewed
• [Journal Article] Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCβ activation in diabetes (2012)
  • Author(s): Mima A
  • Journal Title: Diabetes Volume: 61 Issue: 11 Pages: 2967-2979
  • DOI: 10.2337/db11-1824
  • Peer Reviewed
• [Journal Article] PIASy regulates α-smooth muscle actin expression by interacting with E12 in mesangial cells (2012)
  • Author(s): Torikoshi K. et al.
  • Journal Title: Plos ONE Volume: 7(7) Issue: 7 Pages: e41186-e41186
  • DOI: 10.1371/journal.pone.0041186
  • Peer Reviewed
• [Journal Article] Acute glomerulonephritis in an immunocompetent elderly woman after contact with a child who had been diagnosed as erythema infectiosum (2012)
  • Author(s): Kishi S
  • Journal Title: Intern Med Volume: 51 Pages: 2197-2201
  • Peer Reviewed
• [Journal Article] Implications of treatment that target protective mechanisms against diabetic nephropathy (2012)
  • Author(s): Mima A
  • Journal Title: Semin Nephrol Volume: 32 Issue: 5 Pages: 471-478
  • DOI: 10.1016/j.semnephrol.2012.07.010
  • Peer Reviewed
• [Journal Article] Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes (2012)
  • Author(s): Mima A
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53 Issue: 13 Pages: 8424-8432
  • DOI: 10.1167/iovs.12-10207
  • Peer Reviewed
• [Presentation] (2013)
  • Author(s): 美馬晶、土井俊夫
  • Organizer: 慢性腎臓病第23回日本医療薬学会年会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2013-09-21
• [Presentation] 慢性腎臓病(CKD)の診断、経過観察に必要な検査 (2013)
  • Author(s): 美馬晶
  • Organizer: 第53回日本臨床化学会年次学術集会
  • Place of Presentation: あわぎんホール(徳島県)
  • Year and Date: 2013-09-01
• [Presentation] インクレチン製剤を用いた糖尿病性腎症の新気治療戦略 (2013)
  • Author(s): 美馬晶
  • Organizer: 第53回日本臨床化学会年次学術集会
  • Place of Presentation: あわぎんホール(徳島県)
  • Year and Date: 2013-08-31
• [Presentation] Direct demonstration that overexpression of IRS1 and enhanced insulin actions in vascular endothelial cells can reduce atherosclerosis (2013)
  • Author(s): Park K, Mima A, Li Q, Rask-Madsen C, Chen H, King GL
  • Organizer: 73rd annual meeting of American Diabetes Association
  • Place of Presentation: マコーミックプレイス(アメリカシカゴ)
  • Year and Date: 2013-06-21
• [Presentation] Selective insulin receptor substrate 1 and its functions in glomeruli of diabetic and insulin resistant rats (2012)
  • Author(s): Mima A, King GL, Doi T
  • Organizer: 2012 American Society of Nephrology Annual Meeting
  • Place of Presentation: サンディエゴコンベンションセンター(アメリカサンディエゴ)
  • Year and Date: 2012-11-01
• [Presentation] The effects of diabetes and angiotensin on the loss of glucagon-like peptide-1's protective actions in diabetic endothelial glomerulopathy (2012)
  • Author(s): Mima A, Li Q, Mizutani K, Park K, Rask-Madsen C, King GL
  • Organizer: 72nd annual meeting of American Diabetes Association
  • Place of Presentation: ペンシルバニアコンベンションセンター(アメリカフィラデルフィア)
  • Year and Date: 2012-06-10
• [Presentation] Serine phosphorylation (Ser303) of IRS2 by angiotensin II (AngII) inhibits insulin activation of p-Akt/eNOS in endothelial cells (2012)
  • Author(s): Park K, Li Q, Rask-Madsen C, Mima A, Feener EP, Winnay J, King GL
  • Organizer: 72nd annual meeting of American Diabetes Association
  • Place of Presentation: ペンシルバニアコンベンションセンター(アメリカフィラデルフィア)
  • Year and Date: 2012-06-10
• [Presentation] Obesity induced insulin resistance in gingival tissue and periodontitis via PKC activation and oxidative stress (2012)
  • Author(s): Mizutani K, Mima A, Park K, King GL
  • Organizer: 72nd annual meeting of American Diabetes Association
  • Place of Presentation: ペンシルバニアコンベンションセンター(アメリカフィラデルフィア)
  • Year and Date: 2012-06-10
• [Presentation] Endothelial over expression of PKCβ2 accelerates the development of atherosclerosis (2012)
  • Author(s): Li Q, Park K, Li C, Rask-Madsen C, Mima A, King GL
  • Organizer: 72nd annual meeting of American Diabetes Association
  • Place of Presentation: ペンシルバニアコンベンションセンター(アメリカフィラデルフィア)
  • Year and Date: 2012-06-09
• [Presentation] Diabetes causes persistent insulin resistance and impairment of angiogenic function of mesenchymal stem cells (MSC) by protein kinase Cβ(PKC) activation (2012)
  • Author(s): Mizutani K, Jeong I, Mima A, Li Q, Park K, Rask-Madsen C, Mooney DJ, King GL
  • Organizer: 72nd annual meeting of American Diabetes Association
  • Place of Presentation: ペンシルバニアコンベンションセンター(アメリカフィラデルフィア)
  • Year and Date: 2012-06-09
• [Presentation] Selective Insulin Receptor Substrate 1 and Its Functions in Glomeruli of Diabetic and Insulin Resistant Rats (2012)
  • Author(s): Mima A
  • Organizer: 2012 米国腎臓学会
  • Place of Presentation: San Diego Convention Center（米国）
• [Presentation] Expression of Gas6 and Axl in Human IgA Nephropathy: A Possible Involvement of Gas6 in Podocyte Damage (2012)
  • Author(s): Miyoshi M
  • Organizer: 2012 米国腎臓学会
  • Place of Presentation: San Diego Convention Center（米国）
• [Presentation] インクレチン製剤を用いた糖尿病性腎症の新規治療戦略
  • Author(s): 美馬 晶
  • Organizer: 第53回日本臨床化学会年次学術集会
  • Place of Presentation: あわぎんホール（徳島県）
  • Invited
• [Presentation] 慢性腎臓病(CKD)の診断、経過観察に必要な検査
  • Author(s): 美馬 晶
  • Organizer: 第53回日本臨床化学会年次学術集会
  • Place of Presentation: あわぎんホール（徳島県）
  • Invited
• [Presentation] 慢性腎臓病
  • Author(s): 美馬 晶、土井 俊夫
  • Organizer: 第23回日本医療薬学会年会
  • Place of Presentation: 仙台国際センター（宮城県）
  • Invited
• [Book] 腎不全歯科医師のための医学ハンドブック (2014)
  • Author(s): 美馬晶
  • Total Pages: 222
• [Book] Na+/グルコース共役輸送担体(SGLT2)阻害薬SGLT、GLUTの遺伝子調節と腎性尿糖 (2013)
  • Author(s): 美馬晶、土井俊夫
  • Total Pages: 784
  • Publisher: Diabetes Frontier
• [Book] 脱水老年医学講義テキスト (2013)
  • Author(s): 美馬晶、土井俊夫
  • Total Pages: 327