mutual analysis of intracellular signaling and morphological change in phagosome formation and maturation
| Project/Area Number |
24890154
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General anatomy (including Histology/Embryology)
|
|---|
| Research Institution | Kagawa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ARAKI Nobukazu 香川大学, 医学部, 教授 (10202748)
MIYAKE Katusya 香川大学, 医学部, 准教授 (30219745)
EGAMI Youhei 香川大学, 医学部, 助教 (80432780)
|
|---|
| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | ファゴサイトーシス / Rabタンパク質 / 小胞輸送 / シグナル伝達 / 脂質 |
|---|
| Research Abstract |
Phagocytosis has a crucial role in immune defense and development. In this study, using multicolor living cell imaging, it is found that Rab35 is involved in Fc-gamma receptor mediated phagocytosis. Rab35 is localized in phagocytic cup and maturing phagosome. In maturing phagosome, Rab35 and its effecter molecule, MICAL-L1 are budding form phagosome as tubular structures. These results are suggesting that Rab35/ MICAL-L1 play roles in receptor recycling or antigen presentation in Fc-gamma mediated phagocytosis.
|
Report
(3 results)
Research Products
(5 results)
