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mutual analysis of intracellular signaling and morphological change in phagosome formation and maturation

Research Project

Project/Area Number 24890154
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General anatomy (including Histology/Embryology)
Research InstitutionKagawa University

Principal Investigator

KAWAI katsuhisa  香川大学, 医学部, 助教 (80534510)

Co-Investigator(Renkei-kenkyūsha) ARAKI Nobukazu  香川大学, 医学部, 教授 (10202748)
MIYAKE Katusya  香川大学, 医学部, 准教授 (30219745)
EGAMI Youhei  香川大学, 医学部, 助教 (80432780)
Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsファゴサイトーシス / Rabタンパク質 / 小胞輸送 / シグナル伝達 / 脂質
Research Abstract

Phagocytosis has a crucial role in immune defense and development. In this study, using multicolor living cell imaging, it is found that Rab35 is involved in Fc-gamma receptor mediated phagocytosis. Rab35 is localized in phagocytic cup and maturing phagosome. In maturing phagosome, Rab35 and its effecter molecule, MICAL-L1 are budding form phagosome as tubular structures. These results are suggesting that Rab35/ MICAL-L1 play roles in receptor recycling or antigen presentation in Fc-gamma mediated phagocytosis.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (5 results)

All 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Development of an automated fluorescence microscopy system for photomanipulation of genetically encoded photoactivatable proteins (optogenetics) in live cells.2014

    • Author(s)
      Araki N, Ikeda Y, Kato T, Kawai K, Egami Y, Miyake K, Tsurumaki N, Yamaguchi M.
    • Journal Title

      Microscopy (Oxf).

      Volume: 63 Issue: 3 Pages: 255-260

    • DOI

      10.1093/jmicro/dfu003

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dissecting the roles of Rac1 activation and deactivation in macropinocytosis using microscopic photo-manipulation2013

    • Author(s)
      Fujii, M., Kawai, K., Egami, Y., Araki, N.
    • Journal Title

      Scientific reports

      Volume: 3 Issue: 1 Pages: 2385-2385

    • DOI

      10.1038/srep02385

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] ファゴソーム成熟過程におけるRab35の役割2014

    • Author(s)
      川合克久,江上洋平,荒木伸一
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学(栃木県)
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] マクロファージにおけるファゴサイトーシスへのRab35の関与2013

    • Author(s)
      石川有里恵,川合克久,藤井誠,江上洋平,荒木伸一
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      サンポートホール高松・香川国際会議場(香川県)
    • Related Report
      2013 Final Research Report
  • [Remarks] 香川大学医学部組織細胞生物学

    • URL

      http://www.kms.ac.jp/%7Eanatomy2/index.html

    • Related Report
      2013 Final Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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