Development of environmentally friendly synthetic method for amino acid
| Project/Area Number |
24890158
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
YAZAKI Ryo 九州大学, 薬学研究科(研究院), 助教 (70635812)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アミノ酸 / 触媒 / 環境調和 / 化学選択性 |
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| Research Abstract |
We developed direct catalytic amination reaction of carbonyl compounds under mild reaction conditions. It is noteworthy that desired amination product was chemoselectively obtained even in the presence of ketone or ester. In addition, catalyst-controlled chemoselective hydroxyl group functionalization of amino acid derivatives over innately more reactive amino group was developed. The present catalysis enabled hydroxy group-selective functionalization of N-unprotected serine-containing peptide.
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Report
(3 results)
Research Products
(14 results)
