Crosstalk between androgen receptor signaling and oxidative stress
| Project/Area Number |
24890160
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Kyushu University |
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Principal Investigator |
SHIOTA Masaki 九州大学, 医学(系)研究科(研究院), 助教 (20635445)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 前立腺癌 / アンドロゲン受容体 / 酸化ストレス |
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| Research Abstract |
This study aimed to figure out the interaction between androgen receptor signaling and oxidative stress, and to apply it to clinics. As a result, hormone therapy-induced oxidative stress caused activations of several intracellular signal-transduction pathways. Inversely, antioxidants as well as inhibitors to signal-transduction pathway suppressed androgen receptor expression and prostate cancer growth. As well, anticancer effect of hormone therapy was augmented by these inhibitors. Taken together, antioxidants and these inhibitors seem to be a promising therapeutic to prostate cancer.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Interaction between docetaxel resistance and castration resistance in prostate cancer: Implications of Twist1, YB-1, and androgen receptor2013
Author(s)
Shiota M, Kashiwagi E, Yokomizo A, Takeuchi A, Dejima T, Song Y, Tatsugami K, Inokuchi J, Uchiumi T, Naito S
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Journal Title
Prostate
Volume: 73
Issue: 12
Pages: 1336-44
DOI
Related Report
Peer Reviewed
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[Journal Article] Mutual regulation between Raf/MEK/ERK signaling and Y-box-binding protein-1 promotes prostate cancer progression2013
Author(s)
Imada, K, Shiota, M., Kohashi, K., Kuroiwa, K., Song, Y., Sugimoto, M., Naito, S., Oda, Y.
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Journal Title
Clin. Cancer Res.
Volume: 19(17)
Issue: 17
Pages: 4638-4650
DOI
Related Report
Peer Reviewed
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[Presentation] Y-box binding protein-1 promotes castration-resistant prostate cancer growth via androgen receptor expression2013
Author(s)
Shiota M, Takeuchi A, Song YH, Yokomizo A, Kashiwagi E, Uchiumi T, Kuroiwa K, Tatsugami K, Fujimoto N, Oda Y, Naito S
Organizer
AUA 2013 Annual Meeting
Place of Presentation
San Diego (USA)
Year and Date
2013-05-05
Related Report
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[Presentation] Y-box binding protein-1 promotes castration-resistant prostate cancer growth via androgen receptor expression2013
Author(s)
Shiota M, Takeuchi A, Song YH, Yokomizo A, Kashiwagi E, Uchiumi T, Kuroiwa K, Tatsugami K, Fujimoto N, Oda Y, Naito S
Organizer
AUA 2013 Annual Meeting
Place of Presentation
San Diego
Related Report
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