| Project/Area Number |
24890160
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
SHIOTA Masaki 九州大学, 医学(系)研究科(研究院), 助教 (20635445)
|
|---|
| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 前立腺癌 / アンドロゲン受容体 / 酸化ストレス |
|---|
| Research Abstract |
This study aimed to figure out the interaction between androgen receptor signaling and oxidative stress, and to apply it to clinics. As a result, hormone therapy-induced oxidative stress caused activations of several intracellular signal-transduction pathways. Inversely, antioxidants as well as inhibitors to signal-transduction pathway suppressed androgen receptor expression and prostate cancer growth. As well, anticancer effect of hormone therapy was augmented by these inhibitors. Taken together, antioxidants and these inhibitors seem to be a promising therapeutic to prostate cancer.
|
