Analysis of relationship between periodontal tissue para-inflammation induced neuroinflammation and phagocytic activity regulation by circadian cloclk system
| Project/Area Number |
24890161
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
OKADA Ryo 九州大学, 歯学研究科(研究院), 助教 (70633105)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 歯学 / 歯周パラインフラメーション / 脳炎症 / 食細胞 / 体内時計 |
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| Research Abstract |
To elucidate the mechanism of cognitive impairment by chronic inflammatory periodontal disease, also known as para-inflammation disease, we developed animal models of periodontal disease. After the application of P. gingivalis (PG) to periodontal tissues, proinflammatory cytokines were expressed at the periodontal tissue and cerebral cortex. and intraperitoneal administration of PG caused cognitive impairment.
Microglia involved in cognitive impairment by producing proinflammatory cytokines under neuroinflammatory conditions. And recent studies showed that the abilities of microglia showed circadian rhythm. After the application of PG, proinflammatory cytokine mRNA expression levels in brain microglia and periodontal tissue macrophages showed circadian rhythm. These results suggested that circadian rhythm of proinflammatory cytokine gene expressions by periodontal tissue and brain phagocytes may affect periodontal tissue inflammation and cognitive impairment progression.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin2013
Author(s)
S. Yoshinori Hayashi, Satoru Koyanagi, Naoki Kusunose, Ryo Okada, Zhou Wu, Hidetoshi Tozaki-Saitoh, Kiyoharu Ukai, Shinichi Kohsaka, Kazuhide Inoue, Shigehiro Ohdo, Hiroshi Nakanishi
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Journal Title
Sci. Rep
Volume: 3巻
Pages: 2744-2744
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