Identification of microRNA which play important role in Sjogren's Syndrome
| Project/Area Number |
24890165
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | microRNA / Sjogren症候群 / IFN-gamma / シェーグレン症候群 / miR-181b / IFN-γ / 関節リウマチ / MTX |
|---|
| Research Abstract |
We found miR-181b was up-regulated in Sjogren syndrome (SS) salivary epithelial cells as compared with controls. The stimulation of IFN-gmma decreased the levels of miR-181b. Our data suggested that in SS, miR-181b was up-regulated and IFN-gamma regulates the expression of miR-181b in SS salivary gland. Thereby upregulation of miR-181b might play important role in pathogenesis of SS. Future experiment about function of miR-181b in SS and analysing predicted target of miR-181b are needed.
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Report
(3 results)
Research Products
(27 results)
