Identification of microRNA which play important role in Sjogren's Syndrome

• Project/Area Number: 24890165
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Nagasaki University
• Principal Investigator: IWAMOTO Naoki 長崎大学, 大学病院, 助教 (80437897)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: microRNA / Sjogren症候群 / IFN-gamma / シェーグレン症候群 / miR-181b / IFN-γ / 関節リウマチ / MTX

Research Abstract

We found miR-181b was up-regulated in Sjogren syndrome (SS) salivary epithelial cells as compared with controls. The stimulation of IFN-gmma decreased the levels of miR-181b. Our data suggested that in SS, miR-181b was up-regulated and IFN-gamma regulates the expression of miR-181b in SS salivary gland. Thereby upregulation of miR-181b might play important role in pathogenesis of SS. Future experiment about function of miR-181b in SS and analysing predicted target of miR-181b are needed.

Research Products

• [Journal Article] Methicillin-resistant Staphylococcus aureus-related Septic Pulmonary Embolism and Sacroiliitis Treated with Long-term Linezolid in a Patient with Adult-onset Still's Disease (2014)
  • Author(s): Horai Y, Iwamoto N
  • Journal Title: Intern Med Volume: 53(9) Pages: 1023-7
  • NAID: 130004902969
  • Peer Reviewed
• [Journal Article] Serum interferon-αis a useful biomarker in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (2014)
  • Author(s): Horai Y,Iwamoto N
  • Journal Title: Mod Rheumatol
  • Peer Reviewed
• [Journal Article] Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis (2014)
  • Author(s): Kawashiri SY, Iwamoto N
  • Journal Title: Rheumatology (Oxford)
  • Peer Reviewed
• [Journal Article] Ultrasonographic examination of rheumatoid arthritis patients who are free of physical synovitis : power Doppler subclinical synovitis is associated with bone erosion (2014)
  • Author(s): Kawashiri SY, Iwamoto N.
  • Journal Title: Rheumatology (Oxford) Volume: 53(3) Pages: 562-9
  • NAID: 120006986675
  • Peer Reviewed
• [Journal Article] 血清学的因子、炎症・バイオマーカーによる早期診断の可能性 (2013)
  • Author(s): 岩本直樹,川上純
  • Journal Title: Prog. Med Volume: 33 Pages: 1905-1908
• [Journal Article] A case of adult T-cell leukemia presenting primary Sjögren's syndrome-like symptoms (2013)
  • Author(s): Nakamura H, Iwamoto N
  • Journal Title: Int J Rheum Dis Volume: 16(4) Pages: 489-92
  • NAID: 120006986105
  • Peer Reviewed
• [Journal Article] An elderly patient with chronic active Epstein-Barr virus infection with mixed cryoglobulinemia and review of the literature (2013)
  • Author(s): Ichinose K, Iwamoto N
  • Journal Title: Mod Rheumatol Volume: 23(5) Pages: 1022-8
  • NAID: 10031201164
  • Peer Reviewed
• [Journal Article] 最近の新知見リウマチ科 (2013)
  • Author(s): 岩本直樹,寺田馨,中村秀樹,川上純
  • Journal Title: アダリムマブ Volume: 50(1) Pages: 51-58
• [Journal Article] Significant improvement in MRI-proven bone edema is associated with protection from structural damage in very early RA patients managed using the tight control approach (2013)
  • Author(s): Kita J, Tamai M, Arima K, Kawashiri SY, Horai Y, Iwamoto N
  • Journal Title: Mod Rheumatol Volume: 23 Pages: 254-9
  • NAID: 10031167696
  • Peer Reviewed
• [Journal Article] アダリムマブ：最近の新知見 (2013)
  • Author(s): 岩本直樹
  • Journal Title: リウマチ科 Volume: 50 Pages: 51-58
• [Journal Article] 血清学的因子、炎症・バイオマーカーによる早期診断の可能性 (2013)
  • Author(s): 岩本直樹
  • Journal Title: Progress in Medicine Volume: 33 Pages: 1905-1908
• [Journal Article] 分類不能関節炎に対するアバタセプトの効果-ADJUST試験の結果を中心に- (2012)
  • Author(s): 岩本直樹,川上純
  • Journal Title: リウマチ科 Volume: 48(6) Pages: 647-652
• [Journal Article] Molecular targets for therapy in systemic sclerosis (2012)
  • Author(s): Iwamoto N, Distler O
  • Journal Title: Fibrogenesis Tissue Repair Volume: 1
• [Journal Article] The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DM (2012)
  • Author(s): Koga T, Fujikawa K, Horai Y, Okada A, Kawashiri SY, Iwamoto N
  • Journal Title: Rheumatology (Oxford) Volume: 51(7) Pages: 1278-84
  • NAID: 120006985654
  • Peer Reviewed
• [Journal Article] Magnetic resonance imaging (MRI) detection of synovitis and bone lesions of the wrists and finger joints in early-stage rheumatoid arthritis : comparison of the accuracy of plain MRI-based findings and gadolinium-diethylenetriamine pentaacetic acid-enhanced MRI-based findings (2012)
  • Author(s): Tamai M, Iwamoto N
  • Journal Title: Mod Rheumatol Pages: 22-22
  • NAID: 10031027542
  • Peer Reviewed
• [Journal Article] 分類不能関節炎に対するアバタセプトの効果 (2012)
  • Author(s): 岩本直樹
  • Journal Title: リウマチ科 Volume: 48 Pages: 647-652
• [Presentation] Musculoskeletal ultrasound and Magnetic resonance imaging of the wrists and finger joints in Sjögren's syndrome (SS) with articular manifestations (2014)
  • Author(s): Iwamoto N, Kawakami A
  • Organizer: 第58回日本リウマチ学会総会
  • Place of Presentation: 東京
• [Presentation] トシリズマブ投与経路変更の有用性および安全性の検討 (2014)
  • Author(s): 岩本直樹、川上純
  • Organizer: 第47回九州リウマチ学会
  • Place of Presentation: 長崎
• [Presentation] トシリズマブ投与経路変更の有用性および安全性の検討 (2014)
  • Author(s): 岩本直樹
  • Organizer: 第47回九州リウマチ学会
  • Place of Presentation: 長崎県長崎市 長崎ブリックホール
• [Presentation] Musculoskeletal ultrasound and Magnetic resonance imaging of the wrists and finger joints in Sjögren’s syndrome (SS) with articular manifestations (2014)
  • Author(s): 岩本直樹
  • Organizer: 第58回日本リウマチ学会
  • Place of Presentation: 東京都品川区 グランドプリンスホテル新高輪
• [Presentation] Downregulation of miR-193b in systemic sclerosis contributes to the proliferative vasculopathy via uPA-uPAR independent pathway (2013)
  • Author(s): Iwamoto N, Distler O
  • Organizer: Annual European Congress of Rheumatology EULAR2013
  • Place of Presentation: Madrid Spain
• [Presentation] Downregulation of miR-193b in systemic sclerosis regulates the proliferative vasculopathy by urokinase-type plasminogen activator expression (2013)
  • Author(s): Iwamoto N, Distler O
  • Organizer: 第57回日本リウマチ学会総会
  • Place of Presentation: 東京
• [Presentation] Downregulation of miR-193b in systemic sclerosis regulates the proliferative vasculopathy by urokinase-type plasminogen activator expression. (2013)
  • Author(s): 岩本直樹
  • Organizer: 第57回日本リウマチ学会
  • Place of Presentation: 京都府京都市国立京都国際会館
• [Presentation] Downregulation of miR-193b in systemic sclerosis contributes to the proliferative vasculopathy via uPA-uPAR independent pathway. (2013)
  • Author(s): 岩本直樹
  • Organizer: 2013欧州リウマチ学会
  • Place of Presentation: スペイン
• [Presentation] MicroRNAによる関節リウマチ滑膜細胞の骨芽細胞分化誘導の検討
  • Author(s): 岩本直樹
  • Organizer: 第28回 長崎DDS・再生医療研究会
  • Place of Presentation: 長崎県長崎市 長崎大学医学部 ポンぺ会館
• [Presentation] Downregulation of miR-193b in systemic sclerosis regulates the proliferative vasculopathy by urokinase-type plasminogen activator expression.
  • Author(s): 岩本直樹
  • Organizer: 第15回アジア・太平洋リウマチ学会
  • Place of Presentation: ヨルダン
• [Presentation] 強皮症におけるmicroRNA-193bの発現低下はurokinase-piasminogen type activator(uPA)の産生を誘導し、増殖性血管障害を引き起こす。
  • Author(s): 岩本直樹
  • Organizer: 第56回 日本リウマチ学会
  • Place of Presentation: 京都