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Bone regeneration by gene activated matrix combined with nano-size calcium phosphate particle and minicircle DNA

Research Project

Project/Area Number 24890167
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionNagasaki University

Principal Investigator

MIURA Kei-ichiro  長崎大学, 医歯(薬)学総合研究科, 助教 (10634446)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords骨再生 / Gene Activated Matrix / 口腔外科 / リン酸カルシウム / ナノサイエンス
Research Abstract

By making use of minicircle DNA, this plasmid was sucsessfully made.And we found that cell transplantaiton efficiency of this plasmid was higher than conventional plasmid. After that we prepared minicircle DNA/calcium phosphate particle/collagen composite combined with Green Fluorescent Protein gene, and assessed the material in vivo analysis. During this period, we successfully made nano-submicro calcium phosphate particle and reported the osteoconduction of the material(K Miura,et al.Applied Surface Science.2013). Furthermore, we obtained the knowledge of bone regeneration material(A Matsui,et al.Cleft Palate-Craniofacl J,2013).

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (4 results)

All 2014 2013 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] The Regenerated Bone Quality by Implantation of Octacalcium Phosphate Collagen Composites in a Canine Alveolar Cleft Model2014

    • Author(s)
      Aritsune Matsui,Keiko Matsui,Takuto Handa,Yuji Tanuma, Kei-ichiro Miura, Yuta Kato, Tadashi Kawai,Osamu Suzuki,Shinji Kamakura, Seishi Echigo
    • Journal Title

      Cleft Palate-Craniofacial Journal

      Volume: - Issue: 4 Pages: 420-430

    • DOI

      10.1597/12-096

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2013

    • Author(s)
      Aritsune Matsui, Keiko Matsui, Takuto Handa, Yuji Tanuma, Kei-ichiro Miura, Yuta Kato, Tadashi Kawai, Osamu Suzuki, Shinji Kamakura, Seishi Echigo
    • Journal Title

      The Cleft Palate-Craniofacial Journal

      Volume: (in press) Issue: 2 Pages: 215-220

    • DOI

      10.1597/10-096

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization and bioactivity of nano-submicro octacalcium phosphate/gelatin composite2011

    • Author(s)
      Miura K, Anada T, Honda Y, Shiwaku Y, Kawai T, Echigo S, Takahashi T, Suzuki O
    • Journal Title

      Appl Surf Sci

      Volume: 282 Pages: 138-145

    • DOI

      10.1016/j.apsusc.2013.05.086

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Weijian Zhong、朝比奈泉:骨髄濃縮液による骨組織再生の試み-BMP2との相乗効果の検討-2013

    • Author(s)
      三浦桂一郎、住田吉慶、江頭寿洋、梅林真由美、長井一浩
    • Organizer
      第67回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      栃木
    • Related Report
      2013 Final Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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