Examination of the participation in periodontal pocket formation of oral bacteria and the occlusal trauma

• Project/Area Number: 24890169
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Nagasaki University
• Principal Investigator: KURAMOTO Akiko 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (30631478)
• Project Period (FY): 2012-08-31 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 歯周炎 / 外傷性咬合 / 口腔内細菌 / アタッチメントロス / 免疫複合体

Outline of Final Research Achievements

Both trauma and periodontal inflammation were simultaneously induced in rats. All rats were killed and their maxillary first molars with surrounding tissues were observed histopathologically. We examined participation in periodontal destruction of the occlusal trauma.
Furthermore, we induced periodontitis in rats by Aggregatibacter actinomycetemcomitans or Streptococcus aureus. Periodontal tissues were observed histopathologically. We examined participation in periodontal destruction of the oral bacteria.

Research Products

• [Journal Article] Nakatsu S, Yoshinaga Y, Kuramoto A, Nagano F, Ichimura I, Oshino K, Yoshimura A, Yano Y, Hara Y (2014)
  • Author(s): Nakatsu S, Yoshinaga Y, Kuramoto A, Nagano F, Ichimura I, Oshino K, Yoshimura A, Yano Y, Hara Y
  • Journal Title: Journal of Periodontal Research Volume: 49 Issue: 3 Pages: 314-322
  • DOI: 10.1111/jre.12109
  • Peer Reviewed
• [Journal Article] Gram-positive bacteria as an antigen topically applied into gingival sulcus of immunized rat accelerates periodontal destruction. (2013)
  • Author(s): Nagano F, Kaneko T, Yoshinaga Y, Ukai T, Kuramoto A, Nakatsu S, Oshino K, Ichimura I, Hara Y.
  • Journal Title: Journal of Periodontal Research Volume: 48 Issue: 4 Pages: 420-427
  • DOI: 10.1111/jre.12021
  • Peer Reviewed
• [Presentation] Occlusal trauma accelerates attachment loss at the onset of experimental periodontitis in rats (2013)
  • Author(s): S. Nakatsu, Y. Yoshinaga, A. Kuramoto, F. Nagano, T. Ukai, I. Ichimura, K. Oshino, A. Yoshimura, Y. Yano, Y. Hara
  • Organizer: 10h asian Pacific Sosiety of Periodontology Meeting
  • Place of Presentation: Nara Prefectural New Public Hall
  • Year and Date: 2013-09-03 – 2013-09-04
• [Presentation] occlusal trauma accelerates attachment loss at the onset of experimental periodontitis (2012)
  • Author(s): 中津晋、吉永泰周、藏本明子、長野史子、鵜飼孝、市村育久、押野一志、吉村篤利、矢納義高、原宜興
  • Organizer: 10th asian pacific society of periodontology meeting
  • Place of Presentation: 奈良県奈良市 奈良県新公会堂
• [Presentation] 咬合性外傷は実験的歯周炎の開始期におけるアタッチメントロスを誘導する
  • Author(s): 中津晋、吉永泰周、藏本明子、長野史子、市村育久、押野一志、矢納義高、原宜興
  • Organizer: 日本歯周病学会九州五大学 日本臨床歯周病学会九州支部合同研修会
  • Place of Presentation: 福岡県福岡市 アクロス福岡
• [Presentation] ラットにおけるグラム陽性細菌の感作および歯肉溝内滴下は歯周組織破壊を促進する
  • Author(s): 長野史子、金子高士、吉永泰周、鵜飼孝、藏本明子、高森雄三、野口惠司、原宜興
  • Organizer: 第5回口腔環境制御研究カテゴリー集会
  • Place of Presentation: 長崎県長崎市 長崎大学医学部ポンペ会館