| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
After establishment of CDDP-resistant oral squamous cell carcinoma(OSCC) cell line, we have presented the importance of cIAP2 is an apoptosis inhibitory protein in CDDP resistance of OSCC in the analysis result. Further, we have reported that it is a prognostic factor and,5-FU-sensitive factor expression cIAP2 leads to 5-FU resistance in OSCC previously. These things indicate the possibility of cIAP2 is the target factor of multi-drug resistance. By targeting cIAP2 in OSCC patients refractory to suppress the expression, it may be possible to enhance the effect of chemo-radiation therapy and improve survival. This result is in the middle of writing paper as currently.
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