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Development of novel therapeutics and elucidation of drug resistance mechanisms in oral squamous cell carcinoma

Research Project

Project/Area Number 24890174
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionKumamoto University

Principal Investigator

NAGATA MASASHI  熊本大学, 医学部附属病院, 非常勤診療医師 (10635791)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords口腔癌 / 薬剤耐性 / アポトーシス / 新規治療薬 / 抗がん剤耐性 / 交差耐性機序
Research Abstract

After establishment of CDDP-resistant oral squamous cell carcinoma(OSCC) cell line, we have presented the importance of cIAP2 is an apoptosis inhibitory protein in CDDP resistance of OSCC in the analysis result. Further, we have reported that it is a prognostic factor and,5-FU-sensitive factor expression cIAP2 leads to 5-FU resistance in OSCC previously. These things indicate the possibility of cIAP2 is the target factor of multi-drug resistance. By targeting cIAP2 in OSCC patients refractory to suppress the expression, it may be possible to enhance the effect of chemo-radiation therapy and improve survival. This result is in the middle of writing paper as currently.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (12 results)

All 2014 2013 2012

All Journal Article (2 results) Presentation (10 results) (of which Invited: 2 results)

  • [Journal Article] A low dicer expression is associated with resistance to 5-FU-based chemoradiotherapy and a shorter overall survival in patients with oral squamous cell carcinoma2014

    • Author(s)
      Kawahara K, Nakayama H, Nagata M, Yoshida R, Hirosue A, Tanaka T, Nakagawa Y, Matsuoka Y, Kojima T, Takamune Y, Yoshitake Y, Hiraki A, Shinohara M
    • Journal Title

      Journal of Oral Pathology and Medicine

      Volume: 43(3) Pages: 350-356

    • Related Report
      2013 Final Research Report
  • [Journal Article] Overexpression of fibronectin confers cell adhesion-mediated drug resistance (CAM-DR) against 5-FU in oral squamous cell carcinoma cells2014

    • Author(s)
      Nakagawa Y, Nakayama H, Nagata M, Yoshida R, Kawahara K, Hirosue A, Tanaka T, Yuno A, Matsuoka Y, Kojima T, Yoshitake Y, Hiraki A, Shinohara M
    • Journal Title

      International Journal of Oncology

      Volume: 44(4) Pages: 1376-1384

    • Related Report
      2013 Final Research Report
  • [Presentation] Increased cIAP2 produces cisplatin resistance in a human oral squamous cell carcinoma cell line2013

    • Author(s)
      Masashi Nagata, Hideki Nakayama, Takuya Tanaka, Ryoji Yoshida, Yoshihiro Nakagawa, Kenta Kawahara, Yoshihiro Yoshitake, Akimitsu Hiraki, Masanori Shinohara
    • Organizer
      第72回日本癌学会学術総会,第71回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜,ロイトン札幌
    • Year and Date
      2013-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト口腔扁平上皮癌細胞株を用いたCDDP耐性株の樹立とcIAP2の役割2013

    • Author(s)
      永田将士、中山秀樹、吉田遼司、川原健太、中川純泰、藤家稔久、田中拓也、吉武義泰、平木昭光、篠原正徳
    • Organizer
      第37回頭頸部癌学会
    • Place of Presentation
      京王プラザホテル・東京
    • Year and Date
      2013-06-12
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト口腔扁平上皮癌細胞株を用いたCDDP耐性株の樹立とcIAP2の役割2013

    • Author(s)
      永田将士
    • Organizer
      第37回頭頸部癌学会
    • Place of Presentation
      京王プラザ
    • Related Report
      2013 Annual Research Report
  • [Presentation] The possible role of cIAP2 in resistance to cisplatin in cisplatin-resistant oral squamous cell carcinoma2013

    • Author(s)
      Nagata Masashi
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト口腔扁平上皮癌細胞株を用いたCDDP耐性株の樹立とcIAP2の役割2013

    • Author(s)
      永田将士
    • Organizer
      第37回頭頸部癌学会
    • Place of Presentation
      東京・京王プラザホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] cIAP2発現上昇による口腔扁平上皮癌のシスプラチン耐性について2013

    • Author(s)
      永田将士
    • Organizer
      第72回癌学会学術総会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] The possible role of cIAP2 in cross-resistance to cisplatin in 5-FU-resistant oral aquamous cell carcinoma2012

    • Author(s)
      Masashi Nagata, Hideki Nakayama, Takuya Tanaka, Ryoji Yoshida, Yoshihiro Nakagawa, Kenta Kawahara, Yoshihiro Yoshitake, Kazutoshi Ota, Akimitsu Hiraki, Masanori Shinohara
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌
    • Year and Date
      2012-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 5-FU耐性口腔扁平上皮癌におけるシスプラチン交差耐性へのcIAP2の役割2012

    • Author(s)
      永田将士
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      札幌・ロイトン札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Preoperative Chemoradiotherapy with S-1 followed by Surgery in Patient with Locally advanced Oral Squamous Cell Carcinoma: A Prospective Phase II Trial2012

    • Author(s)
      永田将士
    • Organizer
      17thWorld Congress on Advances in Oncology
    • Place of Presentation
      ギリシャ・Creta Maris Hotel
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The antiapoptotic mechanism underlying drug resistance of oral squamous cell carcinoma2012

    • Author(s)
      中山 秀樹
    • Organizer
      17thWorld Congress on Advances in Oncology
    • Place of Presentation
      ギリシャ・Creta Maris Hotel
    • Related Report
      2012 Annual Research Report
    • Invited

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Published: 2012-11-27   Modified: 2019-07-29  

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