Novel therapy on sarcopenia by targeting Akt signaling
| Project/Area Number |
24890178
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kagoshima University |
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Principal Investigator |
AKASAKI Yuichi 鹿児島大学, 医歯(薬)学総合研究科, 助教 (00631920)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 骨格筋 / 老化 / シグナル伝達 / 糖尿病 / 脂質 / 代謝内科学 |
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| Research Abstract |
Akt1-mediated increase in muscle mass led to reductions in fat mass and hepatic steatosis in older animals, and corrected age-associated impairments in glucose metabolism. These results indicate that the loss of lean muscle mass is a significant contributor to the development of age-related metabolic dysfunction and that interventions that preserve or restore fast/glycolytic muscle may delay the onset of metabolic disease.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Novel therapy for atherosclerosis using recombinant immunotoxin against folate receptor β-expressing macrophages2012
Author(s)
Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C
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Journal Title
Journal of American Heart Association
Volume: 1
Issue: 4
DOI
Related Report
Peer Reviewed
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