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Novel therapy on sarcopenia by targeting Akt signaling

Research Project

Project/Area Number 24890178
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionKagoshima University

Principal Investigator

AKASAKI Yuichi  鹿児島大学, 医歯(薬)学総合研究科, 助教 (00631920)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords骨格筋 / 老化 / シグナル伝達 / 糖尿病 / 脂質 / 代謝内科学
Research Abstract

Akt1-mediated increase in muscle mass led to reductions in fat mass and hepatic steatosis in older animals, and corrected age-associated impairments in glucose metabolism. These results indicate that the loss of lean muscle mass is a significant contributor to the development of age-related metabolic dysfunction and that interventions that preserve or restore fast/glycolytic muscle may delay the onset of metabolic disease.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (8 results)

All 2014 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (1 results) Book (2 results)

  • [Journal Article] Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism2014

    • Author(s)
      Akasaki Y, Ouchi N, Izumiya Y, Bernardo BL, Lebrasseur NK, Walsh K
    • Journal Title

      Aging Cell

      Volume: 13(1) Issue: 1 Pages: 80-91

    • DOI

      10.1111/acel.12153

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel therapy for atherosclerosis using recombinant immunotoxin against folate receptor β-expressing macrophages2012

    • Author(s)
      Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C
    • Journal Title

      Journal of American Heart Association

      Volume: 1 Issue: 4

    • DOI

      10.1161/jaha.112.003079

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Waon therapy upregulates Hsp90 and leads to angiogenesis through the Akt-endothelial nitric oxide synthase pathway in mouse hindlimb ischemia2012

    • Author(s)
      Miyauchi T, Miyata M, Ikeda Y, Akasaki Y, Hamada N, Shirasawa T, Furusho Y, Tei C
    • Journal Title

      Circ J

      Volume: 76(7) Pages: 1712-21

    • NAID

      10030503634

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Akt1-Mediated skeletal muscle growth attenuates cardiac dysfunction and remodeling after experimental myocardial Infarction2012

    • Author(s)
      Araki S, Izumiya Y, Hanatani S, Rokutanda T, Usuku H, Akasaki Y, Takeo T, Nakagata N, Walsh K, Ogawa H
    • Journal Title

      Circ Heart Fail

      Volume: 5 Pages: 116-125

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Waon Therapy Upregulates Hsp90 and Leads to Angiogenesis Through the Akt-Endothelial Nitric Oxide Synthase Pathway in Mouse Hindlimb Ischemia2012

    • Author(s)
      Takahiro Miyauchi
    • Journal Title

      Circulation Journal

      Volume: 76 Issue: 7 Pages: 1712-1721

    • DOI

      10.1253/circj.CJ-11-0915

    • NAID

      10030503634

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 長期食事管理された後期高齢者の脈波伝播速度2014

    • Author(s)
      宮内孝浩,赤崎雄一,大石充
    • Organizer
      日本老年病学会九州地方会(第24回)
    • Place of Presentation
      産業医科大学.北九州市
    • Year and Date
      2014-03-08
    • Related Report
      2013 Final Research Report
  • [Book] カレントテラピー白衣高血圧(低リスクと高リスク)の治療2014

    • Author(s)
      赤崎雄一,大石充
    • Publisher
      ライフメディコム,東京
    • Related Report
      2013 Final Research Report
  • [Book] カレントテラピー 白衣高血圧(低リスクと高リスク)の治療2014

    • Author(s)
      赤崎雄一、大石充
    • Total Pages
      112
    • Publisher
      ライフメディコム
    • Related Report
      2013 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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