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Mechanism of neurite outgrowth promoting effect of LOTUS, an antagonist for Nogo receptor

Research Project

Project/Area Number 24890187
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionYokohama City University

Principal Investigator

KURIHARA Yuji  横浜市立大学, 生命医科学研究科, 特任助教 (00634552)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords神経科学 / 突起伸長 / シグナル伝達 / 神経再生
Research Abstract

LOTUS functions as the antagonist for Nogo receptor-1 (NgR1) which restricts functional recovery after damages to the central nervous system. We found that LOTUS also promotes neurite outgrowth. In this study, I analyzed the promoting effect of LOTUS on neurite outgrowth. Using the neurons from ngr1-deficient mice, I investigated the molecule(s) which mediate the promoting effect of LOTUS on neurite outgrowth. I found that LOTUS interacts with the molecule(s) except for NgR1 and the unidentified LOTUS binding molecule(s) mediate the promoting action of LOTUS on neurite outgrowth.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (9 results)

All 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones2013

    • Author(s)
      Iketani M., Iizuka A., Sengoku K., Kurihara Y., Nakamura F., Sasaki Y., Sato Y., Yamane M., Matsushita M., Nairn A.C., Takamatsu K., Goshima Y., Takei K.
    • Journal Title

      Dev. Neurosci

      Volume: 73 Issue: 3 Pages: 230-246

    • DOI

      10.1002/dneu.22058

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] LOTUSによる神経回路形成機構2013

    • Author(s)
      栗原裕司,竹居光太郎
    • Journal Title

      Annual Review神経2013

      Volume: 2013年発行巻 Pages: 63-67

    • URL

      http://www.chugaiigaku.jp/item/detail.php?id=1180

    • Related Report
      2013 Final Research Report
  • [Journal Article] LOTUSによる神経回路形成機構2013

    • Author(s)
      栗原裕司
    • Journal Title

      Annual Review 神経 2013

      Volume: 2013年発行巻

    • Related Report
      2012 Annual Research Report
  • [Presentation] LOTUSの神経突起伸長作用2013

    • Author(s)
      栗原裕司,伊藤拓夢,池谷真澄,五嶋良郎,竹居光太郎
    • Organizer
      第36回日本神経科学大会&第56回日本神経化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2013-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] LOTUS functions as a potent antagonist for Nogo receptor2012

    • Author(s)
      Kurihara Y, Iketani M, Ito H, Nishiyama K, Sakakibara Y, Goshima Y, Takei K
    • Organizer
      The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry & The 55th Annual Meeting of the Japanese Society for Neurochemistry Kobe
    • Place of Presentation
      Kobe
    • Year and Date
      2012-10-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Nogo受容体に対するLOTUSの拮抗作用2012

    • Author(s)
      栗原裕司,池谷真澄,伊藤拓夢,西山邦幸,榊原裕介,五嶋良郎,竹居光太郎
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation] LOTUSの神経突起伸長作用

    • Author(s)
      栗原 裕司,伊藤 拓夢,池谷 真澄,五嶋 良郎,竹居 光太郎
    • Organizer
      第36回日本神経科学大会・第56回日本神経化学会大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Nogo受容体に対するLOTUSの拮抗作用

    • Author(s)
      栗原 裕司
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] LOTUS functions as a potent antagonist for Nogo receptor

    • Author(s)
      栗原 裕司
    • Organizer
      第11回アジア太平洋神経化学会大会・第55回日本神経化学会大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Related Report
      2012 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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