Mechanism of neurite outgrowth promoting effect of LOTUS, an antagonist for Nogo receptor
Project/Area Number |
24890187
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
General pharmacology
|
Research Institution | Yokohama City University |
Principal Investigator |
KURIHARA Yuji 横浜市立大学, 生命医科学研究科, 特任助教 (00634552)
|
Project Period (FY) |
2012-08-31 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 神経科学 / 突起伸長 / シグナル伝達 / 神経再生 |
Research Abstract |
LOTUS functions as the antagonist for Nogo receptor-1 (NgR1) which restricts functional recovery after damages to the central nervous system. We found that LOTUS also promotes neurite outgrowth. In this study, I analyzed the promoting effect of LOTUS on neurite outgrowth. Using the neurons from ngr1-deficient mice, I investigated the molecule(s) which mediate the promoting effect of LOTUS on neurite outgrowth. I found that LOTUS interacts with the molecule(s) except for NgR1 and the unidentified LOTUS binding molecule(s) mediate the promoting action of LOTUS on neurite outgrowth.
|
Report
(3 results)
Research Products
(9 results)
-
[Journal Article] Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones2013
Author(s)
Iketani M, Iizuka A, Sengoku K, Kurihara Y, Nakamura F, Sasaki Y, Sato Y, Yamane M, Matsushita M, Nairn AC, Takamatsu K, Goshima Y, Takei K
-
Journal Title
Dev Neurobiol
Volume: 73
Pages: 230-246
DOI
Related Report
Peer Reviewed
-
-
-
[Presentation] LOTUSの神経突起伸長作用2013
Author(s)
栗原裕司,伊藤拓夢,池谷真澄,五嶋良郎,竹居光太郎
Organizer
第36回日本神経科学大会&第56回日本神経化学会大会
Place of Presentation
京都
Year and Date
2013-06-21
Related Report
-
[Presentation] LOTUS functions as a potent antagonist for Nogo receptor2012
Author(s)
Kurihara Y, Iketani M, Ito H, Nishiyama K, Sakakibara Y, Goshima Y, Takei K
Organizer
The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry & The 55th Annual Meeting of the Japanese Society for Neurochemistry Kobe
Place of Presentation
Kobe
Year and Date
2012-10-01
Related Report
-
-
-
-